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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Ikaros/IKZF1 Antibody Picoband®

SKU : BHA21000544

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Mfr.No.	PB9643, PB9643-10ug, PB9643-Biotin, PB9643-Cy3, PB9643-Dylight488, PB9643-Dylight550, PB9643-Dylight594, PB9643-FITC, PB9643-HRP, PB9643-APC, PB9643-PE, PB9643-iFluor647, PB9643-carrier-free
Alternative Names	DNA-binding protein Ikaros
Background	DNA-binding protein Ikaros is a protein that in humans is encoded by the IKZF1 gene. This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alteatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Ikaros/IKZF1 Antibody Picoband® catalog # PB9643. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A elemen
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Ikaros, different from the related mouse sequence by five amino acids.
Isotype	Rabbit IgG
Molecular Weight	50-70 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	DNA-binding protein Ikaros;Ikaros family zinc finger protein 1;Lymphoid transcription factor LyF-1;IKZF1;IK1, IKAROS, LYF1, ZNFN1A1;
Tissue Specificity	Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q13422
Gene Id	10320
Gene Name	IKZF1
Sequence	Contains 1 HMG box DNA-binding domain.
Subcellular Location	Nucleus . In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunocytochemistry/Immunofluorescence, 5ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Georgopoulos K, Moore DD, Derfler B (December 1992). "Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment". Science 258 (5083): 80812. 2. Hahm K, Est P, Lo K, Kim GS, Turck C, Smale ST (November 1994). "The lymphoid transcription factor LyF-1 is encoded by specific, alteatively spliced mRNAs derived from the Ikaros gene". Mol Cell Biol 14 (11): 711123.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000544-1	PB9643	100 ug	-	$370		Add to Cart
BHA21000544-2	PB9643-10ug	10 ug	Sample	$99		Add to Cart
BHA21000544-3	PB9643-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000544-4	PB9643-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000544-5	PB9643-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000544-6	PB9643-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000544-7	PB9643-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000544-8	PB9643-FITC	100 ug	FITC	$570		Add to Cart
BHA21000544-9	PB9643-HRP	100 ug	HRP	$570		Add to Cart
BHA21000544-10	PB9643-APC	100 ug	APC	$670		Add to Cart
BHA21000544-11	PB9643-PE	100 ug	PE	$670		Add to Cart
BHA21000544-12	PB9643-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000544-13	PB9643-carrier-free	100 ug	carrier-free	$370		Add to Cart

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