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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IGFBP5 Antibody Picoband®

SKU : BHA21000611

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Mfr.No.	PB9711, PB9711-10ug, PB9711-Biotin, PB9711-Cy3, PB9711-Dylight488, PB9711-Dylight550, PB9711-Dylight594, PB9711-FITC, PB9711-HRP, PB9711-APC, PB9711-PE, PB9711-iFluor647, PB9711-carrier-free
Alternative Names	Insulin-like growth factor-binding protein 5
Background	Insulin-like growth factor-binding protein 5 is a protein that in humans is encoded by the IGFBP5 gene. The expression of IGFBP5 by stable transfection and adenovirus-mediated infection is inhibitory to growth in 2 human breast cancer cell lines. IGFBP5 expression leads to G2/M cell cycle arrest and apoptosis. Stable expression of IGFBP5 in the breast cancer cell lines also inhibits the formation and growth of tumors following injection in athymic mice. It is concluded that IGFBP5 is a growth inhibitor and proapoptotic agent in breast cancer cells. Additionally, IGFBP-5 is expressed by fibroblasts, myoblasts and osteoblasts, making it the predominant IGFBP found in bone extracts. It has a strong affinity for hydroxyapatite, allowing it to bind to bone cells. When bound to extracellular matrix, IGFBP-5 is protected from proteolysis and potentiates IGF activity, but when it is soluble, IGFBP-5 is cleaved to a biologically inactive 21 kDa fragment (1, 2).
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-IGFBP5 Antibody Picoband® catalog # PB9711. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human IGFBP5, different from the related mouse and rat sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	23 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Insulin-like growth factor-binding protein 5;IBP-5;IGF-binding protein 5;IGFBP-5;IGFBP5;IBP5;
Tissue Specificity	Osteosarcoma, and at lower levels in liver, kidney and brain.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P24593
Gene Id	3488
Gene Name	IGFBP5
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, WB
Description	ELISA, 0.1-0.5ug/ml, - Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Allander SV, Larsson C, Ehrenborg E, Suwanichkul A, Weber G, Morris SL, Bajalica S, Kiefer MC, Luthman H, Powell DR (May 1994). "Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5". J Biol Chem 269 (14): 108918. 2. Butt, A. J., Dickson, K. A., McDougall, F., Baxter, R. C. Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo. J. Biol. Chem. 278: 29676-29685, 2003.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000611-1	PB9711	100 ug	-	$370		Add to Cart
BHA21000611-2	PB9711-10ug	10 ug	Sample	$99		Add to Cart
BHA21000611-3	PB9711-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000611-4	PB9711-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000611-5	PB9711-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000611-6	PB9711-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000611-7	PB9711-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000611-8	PB9711-FITC	100 ug	FITC	$570		Add to Cart
BHA21000611-9	PB9711-HRP	100 ug	HRP	$570		Add to Cart
BHA21000611-10	PB9711-APC	100 ug	APC	$670		Add to Cart
BHA21000611-11	PB9711-PE	100 ug	PE	$670		Add to Cart
BHA21000611-12	PB9711-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000611-13	PB9711-carrier-free	100 ug	carrier-free	$370		Add to Cart

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