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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IGF1 Receptor/Igf1r Antibody Picoband®

SKU : BHA21001319

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Mfr.No.	A00070, A00070-10ug, A00070-Biotin, A00070-Cy3, A00070-Dylight488, A00070-Dylight550, A00070-Dylight594, A00070-FITC, A00070-HRP, A00070-APC, A00070-PE, A00070-iFluor647, A00070-carrier-free
Alternative Names	insulin-like growth factor I receptor
Background	IGF1R (Insulin-like Growth Factor 1 (IGF-1) Receptor) is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. The IGF1R gene is mapped on 15q26.3. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Using a yeast 2-hybrid system, it was identified a regulatory subunit of phosphatidylinositol (PI) 3-kinase, PIK3R3, as a binding partner of IGF1R. Functional interaction between BRCA1 and SP1 in the regulation of the IGF1R gene was studied in Schneider cells, a Drosophila cell line which lacks endogenous SP1. In these cells, BRCA1 suppressed 45% of the SP1-induced trans-activation of the IGF1R promoter. Overexpression of the Grb10-binding fragment of Gigyf1 resulted in a significant increase in Igf1-stimulated Igf1r tyrosine phosphorylation. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. IGF-1 activates the Insulin receptor at approximately 0.1x the potency of insulin. Part of this signaling may be via IGF1R-InsulinReceptor heterodimers.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-IGF1 Receptor/Igf1r Antibody Picoband® catalog # A00070. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial f
Host	Rabbit
Immunogen Region	E. coli-derived mouse IGF1 Receptor recombinant protein (Position: E31-K257).
Isotype	Rabbit IgG
Molecular Weight	155 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Insulin-like growth factor 1 receptor; 2.7.10.1; Insulin-like growth factor I receptor; IGF-I receptor; CD221; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; Igf1r;
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Igf1r: Q60751
Gene Id	16001
Gene Name	Igf1r
Subcellular Location	Cell membrane ; Single-pass type I membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Abbott, A. M., Bueno, R., Pedrini, M. T., Murray, J. M., Smith, R. J. Insulin-like growth factor I receptor gene structure. J. Biol. Chem. 267: 10759-10763, 1992.<br /><br />2. Dey, B. R., Furlanetto, R. W., Nissley, S. P. Cloning of human p55-gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. Gene 209: 175-183, 1998.<br /><br />3. Giovannone, B., Lee, E., Laviola, L., Giorgino, F., Cleveland, K. A., Smith, R. J. Two novel proteins that are linked to insulin-like growth factor (IFG-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J. Biol. Chem. 278: 31564-31573, 2003.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001319-1	A00070	100 ug	-	$370		Add to Cart
BHA21001319-2	A00070-10ug	10 ug	Sample	$99		Add to Cart
BHA21001319-3	A00070-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001319-4	A00070-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001319-5	A00070-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001319-6	A00070-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001319-7	A00070-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001319-8	A00070-FITC	100 ug	FITC	$570		Add to Cart
BHA21001319-9	A00070-HRP	100 ug	HRP	$570		Add to Cart
BHA21001319-10	A00070-APC	100 ug	APC	$670		Add to Cart
BHA21001319-11	A00070-PE	100 ug	PE	$670		Add to Cart
BHA21001319-12	A00070-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001319-13	A00070-carrier-free	100 ug	carrier-free	$370		Add to Cart

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