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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Iba1/AIF1 Antibody Picoband®

SKU : BHA21001067

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Mfr.No.	A01394, A01394-10ug, A01394-Biotin, A01394-Cy3, A01394-Dylight488, A01394-Dylight550, A01394-Dylight594, A01394-FITC, A01394-HRP, A01394-APC, A01394-PE, A01394-iFluor647, A01394-carrier-free
Alternative Names	Allograft inflammatory factor 1
Background	Allograft inflammatory factor 1 (AIF-1), also known as ionized calcium-binding adapter molecule 1 (IBA1), is a protein that in humans is encoded by the AIF1 gene. This gene encodes a protein that binds actin and calcium. And this gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alteative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Iba1/AIF1 Antibody Picoband® catalog # A01394. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the p
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Iba1, different from the related mouse sequence by seven amino acids, and from the related rat sequence by six amino acids.
Isotype	Rabbit IgG
Molecular Weight	17 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Allograft inflammatory factor 1;AIF-1;Ionized calcium-binding adapter molecule 1;Protein G1;AIF1;G1, IBA1;
Tissue Specificity	Detected in T-lymphocytes and peripheral blood mononuclear cells. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P55008
Gene Id	199
Gene Name	AIF1
Subcellular Location	Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat<br>

Reference	1. "Entrez Gene: AIF1 allograft inflammatory factor 1".<br /><br />2. Utans U, Arceci RJ, Yamashita Y, Russell ME (June 1995). "Cloning and characterization of allograft inflammatory factor-1: a novel macrophage factor identified in rat cardiac allografts with chronic rejection". J. Clin. Invest. 95 (6): 295462.<br /><br />3. Tian Y, Jain S, Kelemen SE, Autieri MV (February 2009). "AIF-1 expression regulates endothelial cell activation, signal transduction, and vasculogenesis". Am. J. Physiol., Cell Physiol. 296 (2): C25666.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001067-1	A01394	100 ug	-	$370		Add to Cart
BHA21001067-2	A01394-10ug	10 ug	Sample	$99		Add to Cart
BHA21001067-3	A01394-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001067-4	A01394-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001067-5	A01394-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001067-6	A01394-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001067-7	A01394-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001067-8	A01394-FITC	100 ug	FITC	$570		Add to Cart
BHA21001067-9	A01394-HRP	100 ug	HRP	$570		Add to Cart
BHA21001067-10	A01394-APC	100 ug	APC	$670		Add to Cart
BHA21001067-11	A01394-PE	100 ug	PE	$670		Add to Cart
BHA21001067-12	A01394-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001067-13	A01394-carrier-free	100 ug	carrier-free	$370		Add to Cart

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