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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Hyaluronidase-1 HYAL1 Antibody Picoband®

SKU : BHA21007377

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Mfr.No.	PA2181-1, PA2181-1-10ug, PA2181-1-Biotin, PA2181-1-Cy3, PA2181-1-Dylight488, PA2181-1-Dylight550, PA2181-1-Dylight594, PA2181-1-FITC, PA2181-1-HRP, PA2181-1-APC, PA2181-1-PE, PA2181-1-iFluor647, PA2181-1-carrier-free
Alternative Names	Hyaluronidase-1
Background	Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Hyaluronidase-1 HYAL1 Antibody catalog # PA2181-1. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human HYAL1.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human, Monkey, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Hyaluronidase-1;Hyal-1;3.2.1.35;Hyaluronoglucosaminidase-1;Lung carcinoma protein 1;LuCa-1;HYAL1;LUCA1;
Tissue Specificity	Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q12794
Gene Name	HYAL1
Sequence	Belongs to the glycosyl hydrolase 56 family.
Subcellular Location	Secreted . Lysosome .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, ICC, WB
Description	Immunocytochemistry , 0.5-1ug/ml, Human, -<br>Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human, -<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Monkey, Mouse, Rat<br>

Reference	1. Csoka, A. B., Frost, G. I., Heng, H. H. Q., Scherer, S. W., Mohapatra, G., Ste, R. The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus. Genomics 48: 63-70, 1998. Note: Erratum: Genomics 84: 227 only, 2004.<br /><br />2. Martin, D. C., Atmuri, V., Hemming, R. J., Farley, J., Mort, J. S., Byers, S., Hombach-Klonisch, S., Csoka, A. B., Ste, R., Triggs-Raine, B. L. A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis. Hum. Molec. Genet. 17: 1904-1915, 2008. Note: Erratum: Hum. Molec. Genet. 17: 2919 only, 2008. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007377-1	PA2181-1	-	100 ug	$370		Add to Cart
BHA21007377-2	PA2181-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21007377-3	PA2181-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007377-4	PA2181-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007377-5	PA2181-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007377-6	PA2181-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007377-7	PA2181-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007377-8	PA2181-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21007377-9	PA2181-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21007377-10	PA2181-1-APC	APC	100 ug	$670		Add to Cart
BHA21007377-11	PA2181-1-PE	PE	100 ug	$670		Add to Cart
BHA21007377-12	PA2181-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007377-13	PA2181-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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