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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Huntingtin/HTT Antibody Picoband®

SKU : BHA21007435

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Mfr.No.	PA2268, PA2268-10ug, PA2268-Biotin, PA2268-Cy3, PA2268-Dylight488, PA2268-Dylight550, PA2268-Dylight594, PA2268-FITC, PA2268-HRP, PA2268-APC, PA2268-PE, PA2268-iFluor647, PA2268-carrier-free
Alternative Names	Huntingtin
Background	The huntingtin gene, also called HTT or HD (Huntington disease) gene, is the IT15 ("interesting transcript 15") gene which codes for a protein called the huntingtin protein. It is mapped to 4p16.3. The protein has no sequence homology with other proteins and is highly expressed in neurons and tests in humans and rodents. HTT upregulates the expression of Brain Derived Neurotrophic Factor (BDNF) at the transcription level, and this gene is required for normal development. The HTT protein is involved in vesicle trafficking as it interacts with HIP1, a clathrin-binding protein, to mediate endocytosis, the absorption of materials into a cell. HTT was also visualized as punctate staining likely to represent nerve endings. What's more, wildtype HTT may function in the nucleus in the assembly of nuclear matrix-bound protein complexes involved with transcriptional repression and RNA processing.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Huntingtin/HTT Antibody catalog # PA2268. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May play a role in microtubule-mediated transport or vesicle function.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Huntingtin, different from the related mouse and rat sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	348 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Huntingtin;Huntington disease protein;HD protein;HTT;HD, IT15;
Tissue Specificity	Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P42858
Gene Name	HTT
Sequence	Belongs to the huntingtin family.
Subcellular Location	Cytoplasm. Nucleus. The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Kegel, K. B., Meloni, A. R., Yi, Y., Kim, Y. J., Doyle, E., Cuiffo, B. G., Sapp, E., Wang, Y., Qin, Z.-H., Chen, J. D., Nevins, J. R., Aronin, N., DiFiglia, M. Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription. J. Biol. Chem. 277: 7466-7476, 2002.<br /><br />2. The Huntington's Disease Collaborative Research Group (March 1993). "A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes". Cell 72 (6): 97183.<br /><br />3. Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L, MacDonald ME, Friedlander RM, Silani V, Hayden MR, Timmusk T, Sipione S, Cattaneo E (July 2001). "Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease". Science 293(5529): 4938.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007435-1	PA2268	-	100 ug	$370		Add to Cart
BHA21007435-2	PA2268-10ug	Sample	10 ug	$99		Add to Cart
BHA21007435-3	PA2268-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007435-4	PA2268-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007435-5	PA2268-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007435-6	PA2268-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007435-7	PA2268-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007435-8	PA2268-FITC	FITC	100 ug	$570		Add to Cart
BHA21007435-9	PA2268-HRP	HRP	100 ug	$570		Add to Cart
BHA21007435-10	PA2268-APC	APC	100 ug	$670		Add to Cart
BHA21007435-11	PA2268-PE	PE	100 ug	$670		Add to Cart
BHA21007435-12	PA2268-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007435-13	PA2268-carrier-free	carrier-free	100 ug	$370		Add to Cart

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