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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Human Tumor Necrosis Factor Receptor 2 (extracellular) Antibody

SKU : BHA21300839

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Alomone Labs

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Mfr.No.	ANT-042, ANT-042-CF_0.2 ml, ANT-042_0.2 ml, ANT-042_25 mcl, ANT-042_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Human
Background	Tumor Necrosis Factor Receptor 2 (TNFR2) is a member of the TNF receptor superfamily (TNFRSF). TNFR2, together with TNF receptor 1 (TNFR1) are the receptors that transduce signals from the pleiotropic cytokine tumor necrosis factor (TNF) 1.TNF is a 34 kDa type II transmembrane protein (and soluble variant) important in carcinogenesis and immunity. It was found to either promote or suppress the progression of cancer, depending on the receptor it binds. Signaling through TNFR1 induces strong proinflammatory activities and while TNFR2 has proinflammatory effects too, but it also elicits strong anti-inflammatory activities and has an anti-tumor effect 2.TNFR2 expression is rather restricted to certain cell types, including myeloid cells, regulatory T-cells and glial cells. TNFR2 is also frequently expressed on tumor cells and on suppressive immune cells like myeloid-derived suppressor cells 2.Based on these characteristics, TNFR2 agonists have already shown great potential as drugs for cancer therapy, can potentially exert an effect on heart regeneration, and even neuron regeneration in murine models of Parkinson's disease 3.
Clonality	Polyclonal
Description	Anti-Human Tumor Necrosis Factor Receptor 2 (extracellular) Antibody (#ANT-042) is a highly specific antibody directed against an extracellular epitope of the human TNFRSF1B. The antibody can be used in western blot and live cell flow cytometry applications. It has been designed to recognize TNFR2 from human samples only.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	Extracellular, N-terminus.
Isotype	Rabbit IgG
Reactivity	Human
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	TNFR2, Tumor Necrosis Factor Receptor Superfamily Member 1B, TNFRSF1B, Tumor Necrosis Factor Receptor Type II, TNF-RII, CD120b
UNSPSC Code	41116161
Note	Homology: The antibody recognizes only human TNFR2 Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-NT042 Specifictiy: TNFRSF1B AB Specifictiy: Human only Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	P20333
Gene Id	7133
Target	TNFR2, Tumor Necrosis Factor Receptor Superfamily Member 1B, TNFRSF1B, Tumor Necrosis Factor Receptor Type II, TNF-RII, CD120b
Sequence	(C)DQVETQA(S)TREQNR, corresponding to amino acid residues 103 - 116 of human TNFR2

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IFC, LCI, WB
Dilution	Contact Alomone for information

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300839-1	ANT-042-CF_0.2 ml	0.2 ml	$994		Add to Cart
BHA21300839-2	ANT-042_0.2 ml	0.2 ml	$795		Add to Cart
BHA21300839-3	ANT-042_25 mcl	25 mcl	$597		Add to Cart
BHA21300839-4	ANT-042_50 mcl	50 mcl	$697		Add to Cart

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