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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HSP60/HSPD1 Antibody Picoband®

SKU : BHA21006662

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Mfr.No.	PA1106, PA1106-10ug, PA1106-Biotin, PA1106-Cy3, PA1106-Dylight488, PA1106-Dylight550, PA1106-Dylight594, PA1106-FITC, PA1106-HRP, PA1106-APC, PA1106-PE, PA1106-iFluor647, PA1106-carrier-free
Alternative Names	60 kDa heat shock protein, mitochondrial
Background	HSP60 is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNF secretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, NFKB, and TBET expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through TLR2 signaling.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-HSP60/HSPD1 Antibody catalog # PA1106. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress cond
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of rat HSP60, different from the related human sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	70-74 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	60 kDa heat shock protein, mitochondrial;60 kDa chaperonin;Chaperonin 60;CPN60;HSP-65;Heat shock protein 60;HSP-60;Hsp60;Mitochondrial matrix protein P1;Hspd1;Hsp60;
Tissue Specificity	In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg Thimerosal, 0.01mg NaN3.

Uniprot	P63039
Gene Name	HSPD1
Sequence	Belongs to the intermediate filament family.
Subcellular Location	Mitochondrion matrix .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br> Immunocytochemistry , 0.5-1ug/ml, Human, -<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Cheng, M. Y.; Hartl, F.-U.; Martin, J.; Pollock, R. A.; Kalousek, F.; Neupert, W.; Hallberg, E. M.; Hallberg, R. L.; Horwich, A. L. : Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature 337: 620-625, 1989. <br /><br />2. Zanin-Zhorov, A.; Cahalon, L.; Tal, G.; Margalit, R.; Lider, O.; Cohen, I. R. : Heat shock protein 60 enhances CD4+CD25+ regulatory T cell function via innate TLR2 signaling. J. Clin. Invest. 116: 2022-2032, 2006. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006662-1	PA1106	-	100 ug	$370		Add to Cart
BHA21006662-2	PA1106-10ug	Sample	10 ug	$99		Add to Cart
BHA21006662-3	PA1106-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006662-4	PA1106-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006662-5	PA1106-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006662-6	PA1106-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006662-7	PA1106-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006662-8	PA1106-FITC	FITC	100 ug	$570		Add to Cart
BHA21006662-9	PA1106-HRP	HRP	100 ug	$570		Add to Cart
BHA21006662-10	PA1106-APC	APC	100 ug	$670		Add to Cart
BHA21006662-11	PA1106-PE	PE	100 ug	$670		Add to Cart
BHA21006662-12	PA1106-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006662-13	PA1106-carrier-free	carrier-free	100 ug	$370		Add to Cart

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