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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Hsp27/HSPB1 Antibody Picoband®

SKU : BHA21000089

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Mfr.No.	PB9237, PB9237-10ug, PB9237-Biotin, PB9237-Cy3, PB9237-Dylight488, PB9237-Dylight550, PB9237-Dylight594, PB9237-FITC, PB9237-HRP, PB9237-APC, PB9237-PE, PB9237-iFluor647, PB9237-carrier-free
Alternative Names	Heat shock protein beta-1
Background	HSPB1 (Heat shock 27kDa protein 1), also known as HSP27, is a protein that in humans is encoded by the HSPB1 gene. HSP27 gene is mapped to 7q11.23. The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN).
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Hsp27/HSPB1 Antibody Picoband® catalog # PB9237. Tested in Flow Cytometry, IP, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in stress resistance and actin organization.
Host	Rabbit
Immunogen Region	E.coli-derived human Hsp27 recombinant protein (Position: M1-K205). Human Hsp27 shares 83% amino acid (aa) sequence identity with mouse Hsp27.
Isotype	Rabbit IgG
Molecular Weight	27 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Heat shock protein beta-1;HspB1;28 kDa heat shock protein;Estrogen-regulated 24 kDa protein;Heat shock 27 kDa protein;HSP 27;Stress-responsive protein 27;SRP27;HSPB1;HSP27, HSP28;
Tissue Specificity	Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P04792
Gene Id	3315
Gene Name	HSPB1
Sequence	Belongs to the small heat shock protein (HSP20) family.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IP, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human, - Immunocytochemistry/Immunofluorescence, 2ug/ml, Human, - Immunoprecipitation, 0.5-2 ug/ml, Human Flow Cytometry (Fixed), 1-3ug/mlx10⁶ cells, Human, -

Reference	1. Ackerley, S., James, P. A., Kalli, A., French, S., Davies, K. E., Talbot, K. A mutation in the small heat-shock protein HSPB1 leading to distal hereditary motor neuronopathy disrupts neurofilament assembly and the axonal transport of specific cellular cargoes. Hum. Molec. Genet. 15: 347-354, 2006. 2. d'Ydewalle, C., Krishnan, J., Chiheb, D. M., Van Damme, P., Irobi, J., Kozikowski, A. P., Vanden Berghe, P., Timmerman, V., Robberecht, W., Van Den Bosch, L. HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease. Nature Med. 17: 968-974, 2011. 3. Stock, A. D., Spallone, P. A., Dennis, T. R., Netski, D., Morris, C. A., Mervis, C. B., Hobart, H. H. Heat shock protein 27 gene: chromosomal and molecular location and relationship to Williams syndrome. Am. J. Med. Genet. 120A: 320-325, 2003.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000089-1	PB9237	100 ug	-	$370		Add to Cart
BHA21000089-2	PB9237-10ug	10 ug	Sample	$99		Add to Cart
BHA21000089-3	PB9237-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000089-4	PB9237-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000089-5	PB9237-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000089-6	PB9237-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000089-7	PB9237-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000089-8	PB9237-FITC	100 ug	FITC	$570		Add to Cart
BHA21000089-9	PB9237-HRP	100 ug	HRP	$570		Add to Cart
BHA21000089-10	PB9237-APC	100 ug	APC	$670		Add to Cart
BHA21000089-11	PB9237-PE	100 ug	PE	$670		Add to Cart
BHA21000089-12	PB9237-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000089-13	PB9237-carrier-free	100 ug	carrier-free	$370		Add to Cart

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