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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Hsp105/HSPH1 Antibody Picoband®

SKU : BHA21006924

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Mfr.No.	PA1608, PA1608-10ug, PA1608-Biotin, PA1608-Cy3, PA1608-Dylight488, PA1608-Dylight550, PA1608-Dylight594, PA1608-FITC, PA1608-HRP, PA1608-APC, PA1608-PE, PA1608-iFluor647, PA1608-carrier-free
Alternative Names	Heat shock protein 105 kDa
Background	HSP105 (HEAT-SHOCK 105/110-KD PROTEIN 1), also called HSPH1 or HSP110, is a protein that in humans is encoded by the HSPH1 gene. Immunohistochemical analysis localizes HSP105 mainly in the cytoplasm. Database analysis indicates that both HSP105 isoforms are highly conserved during evolution. By analysis of radiation hybrids and human/rodent hybrid cell lines, the HSPH1 gene is mapped to chromosome 13. Both HSP105-alpha and HSP105-beta are upregulated in HeLa cells exposed to heat shock. HSP105-alpha, but not HSP105-beta, is also upregulate in response to other cell stresses. Following heat shock, HSP105 relocalizes from a cytoplasmic to perinuclear position. Besides, HSP110 may thus constitute a major determinant for both prognosis and treatment response in colorectal cancer.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Hsp105/HSPH1 Antibody catalog # PA1608. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Hsp105, different from the related mouse sequence by one amino acid, and different from the related rat sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Heat shock protein 105 kDa;Antigen NY-CO-25;Heat shock 110 kDa protein;HSPH1;HSP105, HSP110, KIAA0201;
Tissue Specificity	Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q92598
Gene Name	HSPH1
Sequence	Belongs to the heat shock protein 70 family.
Subcellular Location	Cytoplasm .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Rat, Human, Mouse <br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Ishihara, K., Yasuda, K., Hatayama, T. Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105. Biochim. Biophys. Acta 1444: 138-142, 1999. <br /><br />2. Dorard, C., de Thonel, A., Collura, A., Marisa, L., Svrcek, M., Lagrange, A., Jego, G., Wanherdrick, K., Joly, A. L., Buhard, O., Gobbo, J., Penard-Lacronique, V., and 16 others. Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis. Nature Med. 17: 1283-1289, 2011. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006924-1	PA1608	-	100 ug	$370		Add to Cart
BHA21006924-2	PA1608-10ug	Sample	10 ug	$99		Add to Cart
BHA21006924-3	PA1608-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006924-4	PA1608-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006924-5	PA1608-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006924-6	PA1608-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006924-7	PA1608-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006924-8	PA1608-FITC	FITC	100 ug	$570		Add to Cart
BHA21006924-9	PA1608-HRP	HRP	100 ug	$570		Add to Cart
BHA21006924-10	PA1608-APC	APC	100 ug	$670		Add to Cart
BHA21006924-11	PA1608-PE	PE	100 ug	$670		Add to Cart
BHA21006924-12	PA1608-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006924-13	PA1608-carrier-free	carrier-free	100 ug	$370		Add to Cart

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