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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HSD17B2 Antibody Picoband®

SKU : BHA21003006

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Mfr.No.	A02506, A02506-10ug, A02506-Biotin, A02506-Cy3, A02506-Dylight488, A02506-Dylight550, A02506-Dylight594, A02506-FITC, A02506-HRP, A02506-APC, A02506-PE, A02506-iFluor647, A02506-carrier-free
Alternative Names	TNF receptor superfamily member 4
Background	HSD17B2 (17-BETA-HYDROXYSTEROID DEHYDROGENASE II), also called 17-BETA-HSD II, is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum. Its Cytogenetic location is 16q23.3. The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42 (43%) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And HSD17B2 activity distinguishing between disease-free and diseased endometria. HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HSD17B2 Antibody Picoband® catalog # A02506. Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity). .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human HSD17B2.
Isotype	Rabbit IgG
Molecular Weight	40 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Tumor necrosis factor receptor superfamily member 4; MRC OX40; OX40 antigen; OX40L receptor; CD134; Tnfrsf4; Ox40; Txgp1l
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P37059
Gene Id	3294
Gene Name	HSD17B2
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, Flow Cytometry
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Berube, D., Luu-The, V., Simard, J., Gagne, R., Labrie, F. Localization of the beta-estradiol dehydrogenase genes to q11-q12 of chromosome 17. (Abstract) Cytogenet. Cell Genet. 51: 962 only, 1989.<br /><br />2. Geissler, W. M., Davis, D. L., Wu, L., Bradshaw, K. D., Patel, S., Mendonca, B. B., Elliston, K. O., Wilson, J. D., Russell, D. W., Andersson, S. Male pseudohermaphroditism caused by mutations of testicular 17-beta-hydroxysteroid dehydrogenase <br /><br />3. Nature Genet. 7: 34-39, 1994. 3. Harkness, R. A., Thistlethwaite, D., Darling, J. A. B., Skakkebaek, N. E., Corker, C. S. Neutral 17-beta-hydroxysteroid oxidoreductase deficiency in testes causing male pseudohermaphroditism in an infant. J. Inherit. Metab. Dis. 2: 51-54, 1979.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003006-1	A02506	-	100 ug	$370		Add to Cart
BHA21003006-2	A02506-10ug	Sample	10 ug	$99		Add to Cart
BHA21003006-3	A02506-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003006-4	A02506-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003006-5	A02506-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003006-6	A02506-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003006-7	A02506-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003006-8	A02506-FITC	FITC	100 ug	$570		Add to Cart
BHA21003006-9	A02506-HRP	HRP	100 ug	$570		Add to Cart
BHA21003006-10	A02506-APC	APC	100 ug	$670		Add to Cart
BHA21003006-11	A02506-PE	PE	100 ug	$670		Add to Cart
BHA21003006-12	A02506-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003006-13	A02506-carrier-free	carrier-free	100 ug	$370		Add to Cart

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