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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HSD17B1 Antibody Picoband®

SKU : BHA21006927

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Mfr.No.	PA1613-1, PA1613-1-10ug, PA1613-1-Biotin, PA1613-1-Cy3, PA1613-1-Dylight488, PA1613-1-Dylight550, PA1613-1-Dylight594, PA1613-1-FITC, PA1613-1-HRP, PA1613-1-APC, PA1613-1-PE, PA1613-1-iFluor647, PA1613-1-carrier-free
Alternative Names	Estradiol 17-beta-dehydrogenase 1
Background	Estradiol 17-beta-dehydrogenase 1 is an enzyme that in humans is encoded by the HSD17B1 gene. This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-HSD17B1 Antibody catalog # PA1613-1. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human HSD17B1, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	37-38 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Estradiol 17-beta-dehydrogenase 1;1.1.1.62;17-beta-hydroxysteroid dehydrogenase type 1;17-beta-HSD 1;20 alpha-hydroxysteroid dehydrogenase;20-alpha-HSD;E2DH;Placental 17-beta-hydroxysteroid dehydrogenase;Short chain dehydrogenase/reductase family 28C member 1;HSD17B1;E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1;
Tissue Specificity	Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P14061
Gene Name	HSD17B1
Sequence	Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, By Heat<br> Immunocytochemistry , 0.5-1ug/ml, Human<br>

Reference	1. "Entrez Gene: HSD17B1 Hydroxysteroid (17-beta) dehydrogenase 1".<br /><br />2. Aka JA, Mazumdar M, Chen CQ, Poirier D, Lin SX (Apr 2010). "17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production".Molecular Endocrinology. 24 (4): 83245. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006927-1	PA1613-1	-	100 ug	$370		Add to Cart
BHA21006927-2	PA1613-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21006927-3	PA1613-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006927-4	PA1613-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006927-5	PA1613-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006927-6	PA1613-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006927-7	PA1613-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006927-8	PA1613-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21006927-9	PA1613-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21006927-10	PA1613-1-APC	APC	100 ug	$670		Add to Cart
BHA21006927-11	PA1613-1-PE	PE	100 ug	$670		Add to Cart
BHA21006927-12	PA1613-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006927-13	PA1613-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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