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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HSD11B1 Antibody Picoband®

SKU : BHA21003955

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Mfr.No.	A01565, A01565-10ug, A01565-Biotin, A01565-Cy3, A01565-Dylight488, A01565-Dylight550, A01565-Dylight594, A01565-FITC, A01565-HRP, A01565-APC, A01565-PE, A01565-iFluor647, A01565-carrier-free
Alternative Names	BUB1 mitotic checkpoint serine/threonine kinase B
Background	11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Tannin et al.(1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al.(2000) mapped the HSD11B1 gene to 1q32-q41.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HSD11B1 Antibody Picoband® catalog # A01565. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity o
Host	Rabbit
Immunogen Region	E.coli-derived human HSD11B1 recombinant protein (Position: E30-K292).
Isotype	Rabbit IgG
Molecular Weight	36 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MAD3/BUB1-related protein kinase; Hbubr1; Mitotic checkpoint kinase MAD3L; Protein SSK1; BUB1B; BUBR1, MAD3L, SSK1
Tissue Specificity	Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P28845
Gene Id	3290
Gene Name	HSD11B1
Subcellular Location	Membrane; Colocalizes with CACNA1A in lipid raft fractions.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ELISA
Description	Weste blot, 0.1-0.25 ug/ml, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. "Entrez Gene: HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1".

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003955-1	A01565	-	100 ug	$370		Add to Cart
BHA21003955-2	A01565-10ug	Sample	10 ug	$99		Add to Cart
BHA21003955-3	A01565-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003955-4	A01565-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003955-5	A01565-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003955-6	A01565-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003955-7	A01565-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003955-8	A01565-FITC	FITC	100 ug	$570		Add to Cart
BHA21003955-9	A01565-HRP	HRP	100 ug	$570		Add to Cart
BHA21003955-10	A01565-APC	APC	100 ug	$670		Add to Cart
BHA21003955-11	A01565-PE	PE	100 ug	$670		Add to Cart
BHA21003955-12	A01565-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003955-13	A01565-carrier-free	carrier-free	100 ug	$370		Add to Cart

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