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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HIP1R Antibody Picoband®

SKU : BHA21003479

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Mfr.No.	A05059-2, A05059-2-10ug, A05059-2-Biotin, A05059-2-Cy3, A05059-2-Dylight488, A05059-2-Dylight550, A05059-2-Dylight594, A05059-2-FITC, A05059-2-HRP, A05059-2-APC, A05059-2-PE, A05059-2-iFluor647, A05059-2-carrier-free
Alternative Names	centriolar coiled-coil protein 110
Background	Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the HIP1R gene. Huntingtin-interacting protein 1-related protein, or HIP1R, was identified on the basis of its structural homology with Huntingtin-interacting protein 1, or HIP1. Based on its domain structure, HIP1R is a putative endocytosis-related protein. Knockdown of HIP1R impairs the endocytosis of activated epidermal growth factor receptor (EGFR) and the consequent activation of the downstream ERK and Akt proteins. Additionally, HIP1R is a component of the clathrin-coated pits and vesicles, which in part links the endocytic machinery to the actin cytoskeleton. It binds to 3-phosphoinositides via ENTH domains to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. HIP1R deficiency significantly reduces the expression of the ionotropic glutamate receptor GluA1, GluN2A, and GluN2B subunits, but not the GABAA receptor alpha1 subunit. Knockdown of HIP1R reduces the amplitude and frequency of the miniature excitatory postsynaptic current, but not of the miniature inhibitory postsynaptic curren. HIP1R has been identified as a protein that can target histone deacetylase-3-mediated neurodegeneration, along with other proteins like NPTX1, NFL, TEX10, and TGFFG.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HIP1R Antibody Picoband® catalog # A05059-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:176
Host	Rabbit
Immunogen Region	E.coli-derived human HIP1R recombinant protein (Position: E316-E734).
Isotype	Rabbit IgG
Molecular Weight	120 kDa
Reactivity	Human, Mouse, Rat, Monkey
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Centriolar coiled-coil protein of 110 kDa; Centrosomal protein of 110 kDa; CP110; Cep110; CCP110; CEP110; CP110; KIAA0419
Tissue Specificity	Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	O75146
Gene Id	9026
Gene Name	HIP1R
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat, Monkey<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Bradley, S. V., Hyun, T. S., Oravecz-Wilson, K. I., Li, L., Waldorff, E. I., Ermilov, A. N., Goldstein, S. A., Zhang, C. X., Drubin, D. G., Varela, K., Parlow, A., Dlugosz, A. A., Ross, T. S. Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1. Hum. Molec. Genet. 16: 1279-1292, 2007.<br /><br />2. Chopra, V. S., Metzler, M., Rasper, D. M., Engqvist-Goldstein, A. E. Y., Singaraja, R., Gan, L., Fichter, K. M., McCutcheon, K., Drubin, D., Nicholson, D. W., Hayden, M. R. HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin. Mammalian Genome 11: 1006-1015, 2000. <br /><br />3. Engqvist-Goldstein, A. E. Y., Kessels, M. M., Chopra, V. S., Hayden, M. R., Drubin, D. G. An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles. J. Cell Biol. 147: 1503-1518, 1999.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003479-1	A05059-2	-	100 ug	$370		Add to Cart
BHA21003479-2	A05059-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003479-3	A05059-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003479-4	A05059-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003479-5	A05059-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003479-6	A05059-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003479-7	A05059-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003479-8	A05059-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003479-9	A05059-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003479-10	A05059-2-APC	APC	100 ug	$670		Add to Cart
BHA21003479-11	A05059-2-PE	PE	100 ug	$670		Add to Cart
BHA21003479-12	A05059-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003479-13	A05059-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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