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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HEXA Antibody Picoband®

SKU : BHA21007055

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Mfr.No.	PA1787, PA1787-10ug, PA1787-Biotin, PA1787-Cy3, PA1787-Dylight488, PA1787-Dylight550, PA1787-Dylight594, PA1787-FITC, PA1787-HRP, PA1787-APC, PA1787-PE, PA1787-iFluor647, PA1787-carrier-free
Alternative Names	Beta-hexosaminidase subunit alpha
Background	HEXA (hexosaminidase A (alpha polypeptide)) is an enzyme that in humans is encoded by the HEXA gene. Hexosaminidase A and the cofactor GM2 activator protein catalyze the degradation of the GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines The HEXA gene encodes the alpha subunit of hexosaminidase A, a lysosomal enzyme involved in the breakdown of gangliosides. The HEXA gene is mapped on 15q23. Even though the alpha and beta subunits of hexosaminidase A can both cleave GalNAc residues, only the alpha subunit is able to hydrolyze GM2 gangliosides. The alpha subunit contains a key residue, Arg-424, which is essential for binding the N-acetyl-neuramanic residue of GM2 gangliosides. Chimeric constructs were expressed in HeLa cells and selected constructs were produced in the baculovirus expression system to determine their ability to degrade GM2 ganglioside in the presence of GM2 activator protein. Their results allowed them to define 2 noncontiguous sequences in the alpha subunit (amino acids 1-191 and 403-529) which, when substituted into analogous positions in the beta subunit, conferred activity against the sulfated substrate.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-HEXA Antibody catalog # PA1787. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human HEXA, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	61 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Beta-hexosaminidase subunit alpha;3.2.1.52;Beta-N-acetylhexosaminidase subunit alpha;Hexosaminidase subunit A;N-acetyl-beta-glucosaminidase subunit alpha;HEXA;
Tissue Specificity	Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P06865
Gene Name	HEXA
Sequence	Belongs to the glycosyl hydrolase 20 family.
Subcellular Location	Lysosome.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Akli, S., Chomel, J.-C., Lacorte, J.-M., Bachner, L., Poenaru, A., Poenaru, L. Ten novel mutations in the HEXA gene in non-Jewish Tay-Sachs patients. Hum. Molec. Genet. 2: 61-67, 1993. <br /><br />2. Beutler, E., Kuhl, W., Comings, D. Hexosaminidase isozyme in type O Gm2 gangliosidosis (Sandhoff-Jatzkewitz disease). Am. J. Hum. Genet. 27: 628-638, 1975.<br /><br />3. Che, C. J., Beutler, E., Kuhl, W., Gilbert, F., Mellman, W. J., Croce, C. M. Characterization of heteropolymeric hexosaminidase A in human x mouse hybrid cells. Proc. Nat. Acad. Sci. 73: 3637-3640, 1976.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007055-1	PA1787	-	100 ug	$370		Add to Cart
BHA21007055-2	PA1787-10ug	Sample	10 ug	$99		Add to Cart
BHA21007055-3	PA1787-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007055-4	PA1787-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007055-5	PA1787-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007055-6	PA1787-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007055-7	PA1787-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007055-8	PA1787-FITC	FITC	100 ug	$570		Add to Cart
BHA21007055-9	PA1787-HRP	HRP	100 ug	$570		Add to Cart
BHA21007055-10	PA1787-APC	APC	100 ug	$670		Add to Cart
BHA21007055-11	PA1787-PE	PE	100 ug	$670		Add to Cart
BHA21007055-12	PA1787-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007055-13	PA1787-carrier-free	carrier-free	100 ug	$370		Add to Cart

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