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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Heparan Sulfate Proteoglycan 2/HSPG2 Antibody Picoband®

SKU : BHA21000184

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Mfr.No.	PB9277, PB9277-10ug, PB9277-Biotin, PB9277-Cy3, PB9277-Dylight488, PB9277-Dylight550, PB9277-Dylight594, PB9277-FITC, PB9277-HRP, PB9277-APC, PB9277-PE, PB9277-iFluor647, PB9277-carrier-free
Alternative Names	Basement membrane-specific heparan sulfate proteoglycan core protein
Background	Perlecan (PLC) also known as HSPG2, is a protein that in humans is encoded by the HSPG2 gene. It is mapped to 1p36.12. Perlecan is highly conserved across species and the available data indicate that it has evolved from ancient ancestors by gene duplication and exonshuffling. Perlecan is a key component of the vascular extracellular matrix, here it interacts with a variety of other matrix components and helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. Perlecan can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Heparan Sulfate Proteoglycan 2/HSPG2 Antibody Picoband® catalog # PB9277. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachm
Host	Rabbit
Immunogen Region	E.coli-derived human HSPG2 recombinant protein (Position: F524-K701). Human HSPG2 shares 86% amino acid (aa) sequence identity with mouse HSPG2.
Isotype	Rabbit IgG
Molecular Weight	469 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Basement membrane-specific heparan sulfate proteoglycan core protein;HSPG;Perlecan;PLC;Endorepellin;LG3 peptide;HSPG2;
Tissue Specificity	Found in the basement membranes.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P98160
Gene Id	3339
Gene Name	HSPG2
Sequence	Contains 4 EGF-like domains.
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Arikawa-Hirasawa E, Le AH, Nishino I, Nonaka I, Ho NC, Francomano CA et al. (May 2002). 2. Iozzo RV (1994). "Perlecan: a gem of a proteoglycan". Matrix Biol. 14 (3): 2038. 3. Kallunki P, Eddy RL, Byers MG, Kestilä M, Shows TB, Tryggvason K (October 1991). "Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1----p35 and identification of a BamHI restriction fragment length polymorphism". Genomics 11 (2): 38996.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000184-1	PB9277	100 ug	-	$370		Add to Cart
BHA21000184-2	PB9277-10ug	10 ug	Sample	$99		Add to Cart
BHA21000184-3	PB9277-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000184-4	PB9277-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000184-5	PB9277-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000184-6	PB9277-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000184-7	PB9277-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000184-8	PB9277-FITC	100 ug	FITC	$570		Add to Cart
BHA21000184-9	PB9277-HRP	100 ug	HRP	$570		Add to Cart
BHA21000184-10	PB9277-APC	100 ug	APC	$670		Add to Cart
BHA21000184-11	PB9277-PE	100 ug	PE	$670		Add to Cart
BHA21000184-12	PB9277-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000184-13	PB9277-carrier-free	100 ug	carrier-free	$370		Add to Cart

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