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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HDAC5 Antibody Picoband®

SKU : BHA21002921

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Mfr.No.	A01230-6, A01230-6-10ug, A01230-6-Biotin, A01230-6-Cy3, A01230-6-Dylight488, A01230-6-Dylight550, A01230-6-Dylight594, A01230-6-FITC, A01230-6-HRP, A01230-6-APC, A01230-6-PE, A01230-6-iFluor647, A01230-6-carrier-free
Alternative Names	histone deacetylase 5
Background	Histone deacetylase 5, also called HDAC5 or KIAA0600, is an enzyme that in humans is encodes by the HDAC5 gene. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. This gene is mapped to 17q21.31. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is though to be associated with colon cancer.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HDAC5 Antibody Picoband® catalog # A01230-6. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progr
Host	Rabbit
Immunogen Region	E.coli-derived human HDAC5 recombinant protein (Position: R13-H1107).
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Histone deacetylase 5; HD5; Antigen NY-CO-9; HDAC5; KIAA0600
Tissue Specificity	Ubiquitous.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	Q9UQL6
Gene Id	10014
Gene Name	HDAC5
Subcellular Location	Nucleus. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Mouse<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x106 cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. McKinsey, T. A., Zhang, C.-L., Lu, J., Olson, E. N. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408: 106-111, 2000.<br /><br />2. Potthoff, M. J., Wu, H., Aold, M. A., Shelton, J. M., Backs, J., McAnally, J., Richardson, J. A., Bassel-Duby, R., Olson, E. N. Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J. Clin. Invest. 117: 2459-2467, 2007.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002921-1	A01230-6	-	100 ug	$370		Add to Cart
BHA21002921-2	A01230-6-10ug	Sample	10 ug	$99		Add to Cart
BHA21002921-3	A01230-6-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002921-4	A01230-6-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002921-5	A01230-6-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002921-6	A01230-6-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002921-7	A01230-6-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002921-8	A01230-6-FITC	FITC	100 ug	$570		Add to Cart
BHA21002921-9	A01230-6-HRP	HRP	100 ug	$570		Add to Cart
BHA21002921-10	A01230-6-APC	APC	100 ug	$670		Add to Cart
BHA21002921-11	A01230-6-PE	PE	100 ug	$670		Add to Cart
BHA21002921-12	A01230-6-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002921-13	A01230-6-carrier-free	carrier-free	100 ug	$370		Add to Cart

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