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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HDAC3 Antibody Picoband®

SKU : BHA21002226

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Mfr.No.	A00839, A00839-10ug, A00839-Biotin, A00839-Cy3, A00839-Dylight488, A00839-Dylight550, A00839-Dylight594, A00839-FITC, A00839-HRP, A00839-APC, A00839-PE, A00839-iFluor647, A00839-carrier-free
Alternative Names	histone deacetylase 3
Background	HDAC3 (HISTONE DEACETYLASE 3) is a member of the histone deacetylase/acuc/apha family of proteins that is an enzyme that in humans is encoded by the HDAC3 gene. The HDAC3 gene is mapped to 5q31.3. HDAC3 has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. The protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. And this gene is regarded as a potential tumor suppressor gene. HDAC3 has an open reading frame of 428 amino acids and shares 53% amino acid identity with HDAC1 and 52% with HDAC2. The catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor NCOR2. All experimental conditions leading to the suppression of HDAC4 binding to NCOR2 and to HDAC3 resulted in loss of enzymatic activity associated with HDAC4. HDAC3 recruitment to the genome displays a circadian rhythm in mouse liver.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HDAC3 Antibody Picoband® catalog # A00839. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in trans
Host	Rabbit
Immunogen Region	E.coli-derived human HDAC3 recombinant protein (Position: M1-I428).
Isotype	Rabbit IgG
Molecular Weight	49 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Histone deacetylase 3; HD3; RPD3-2; SMAP45; HDAC3
Tissue Specificity	Widely expressed.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	O15379
Gene Id	8841
Gene Name	HDAC3
Subcellular Location	Cytosol. Nucleus. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, WB
Description	Western blot, 0.1-0.5ug/ml<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Alenghat, T., Meyers, K., Mullican, S. E., Leitner, K., Adeniji-Adele, A., Avila, J., Bucan, M., Ahima, R. S., Kaestner, K. H., Lazar, M. A. Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature 456: 997-1000, 2008.<br /><br />2. Chen, L., Fischle, W., Verdin, E., Greene, W. C. Duration of nuclear NF-kappa-B action regulated by reversible acetylation. Science 293: 1653-1657, 2001.<br /><br />3. Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR (Mar 1998). "Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells". Biochem Biophys Res Commun 242 (3): 64852. doi:10.1006/bbrc.1997.8033.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002226-1	A00839	-	100 ug	$370		Add to Cart
BHA21002226-2	A00839-10ug	Sample	10 ug	$99		Add to Cart
BHA21002226-3	A00839-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002226-4	A00839-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002226-5	A00839-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002226-6	A00839-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002226-7	A00839-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002226-8	A00839-FITC	FITC	100 ug	$570		Add to Cart
BHA21002226-9	A00839-HRP	HRP	100 ug	$570		Add to Cart
BHA21002226-10	A00839-APC	APC	100 ug	$670		Add to Cart
BHA21002226-11	A00839-PE	PE	100 ug	$670		Add to Cart
BHA21002226-12	A00839-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002226-13	A00839-carrier-free	carrier-free	100 ug	$370		Add to Cart

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