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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HCN1 Antibody Picoband®

SKU : BHA21000126

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Mfr.No.	PB9210, PB9210-10ug, PB9210-Biotin, PB9210-Cy3, PB9210-Dylight488, PB9210-Dylight550, PB9210-Dylight594, PB9210-FITC, PB9210-HRP, PB9210-APC, PB9210-PE, PB9210-iFluor647, PB9210-carrier-free
Alternative Names	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Background	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, also known as HAC-2 or BCNG-1, is a protein that in humans is encoded by the HCN1 gene. It is mapped to 5p12. The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. It may mediates responses to sour stimuli.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-HCN1 Antibody Picoband® catalog # PB9210. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. .
Host	Rabbit
Immunogen Region	E.coli-derived human HCN1 recombinant protein (Position: E618-L890). Human HCN1 shares 82% amino acid (aa) sequence identity with both mouse and rat HCN1.
Isotype	Rabbit IgG
Molecular Weight	120 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1;Brain cyclic nucleotide-gated channel 1;BCNG-1;HCN1;BCNG1;
Tissue Specificity	Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O60741
Gene Id	348980
Gene Name	HCN1
Sequence	Belongs to the potassium channel HCN family.
Subcellular Location	Cell membrane ; Multi-pass membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. Santoro B, Grant SG, Bartsch D, Kandel ER (Feb 1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc Natl Acad Sci U S A 94 (26): 1481520. 2. Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (Jul 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell 93 (5): 71729. 3. Hofmann F, Biel M, Kaupp UB (Dec 2005). "Inteational Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev 57 (4): 45562. 4. "Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1"

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000126-1	PB9210	100 ug	-	$370		Add to Cart
BHA21000126-2	PB9210-10ug	10 ug	Sample	$99		Add to Cart
BHA21000126-3	PB9210-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000126-4	PB9210-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000126-5	PB9210-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000126-6	PB9210-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000126-7	PB9210-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000126-8	PB9210-FITC	100 ug	FITC	$570		Add to Cart
BHA21000126-9	PB9210-HRP	100 ug	HRP	$570		Add to Cart
BHA21000126-10	PB9210-APC	100 ug	APC	$670		Add to Cart
BHA21000126-11	PB9210-PE	100 ug	PE	$670		Add to Cart
BHA21000126-12	PB9210-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000126-13	PB9210-carrier-free	100 ug	carrier-free	$370		Add to Cart

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