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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Hamartin/TSC1 Antibody Picoband®

SKU : BHA21000026

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Mfr.No.	PB9120, PB9120-10ug, PB9120-Biotin, PB9120-Cy3, PB9120-Dylight488, PB9120-Dylight550, PB9120-Dylight594, PB9120-FITC, PB9120-HRP, PB9120-APC, PB9120-PE, PB9120-iFluor647, PB9120-carrier-free
Alternative Names	Hamartin
Background	Hamartin also known as tuberous sclerosis 1 is a protein that in humans is encoded by the TSC1 gene. It is mapped to 9q34.13. This peripheral membrane protein was implicated as a tumor suppressor. It forms a complex with TSC2 that regulates mTORC1 signaling and may be also involved in vesicular transport and docking. Hamartin and TSC2 have critical roles in neuronal polarity, and that a common pathway regulates polarization and growth in neurons and cell size in other tissues. Hamartin is a growth inhibitory protein whose biologic effect is probably dependent on its interaction with tuberin. It also can affect cell proliferation via deregulation of G1 phase. Loss or perturbation of Hamartin function leads to loss of adhesion to the cellular matrix and initiates the development of TSC hamartomas.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Hamartin/TSC1 Antibody Picoband® catalog # PB9120. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor.
Host	Rabbit
Immunogen Region	E.coli-derived human Hamartin recombinant protein (Position: D686-Y884). Human Hamartin shares 96% and 95% amino acid (aa) sequences identity with mouse and rat Hamartin, respectively.
Isotype	Rabbit IgG
Molecular Weight	130 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Hamartin;Tuberous sclerosis 1 protein;TSC1;KIAA0243, TSC;
Tissue Specificity	Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q92574
Gene Id	7248
Gene Name	TSC1
Sequence	Belongs to the AP-2 family.
Subcellular Location	Cytoplasm . Membrane ; Peripheral membrane protein . At steady state found in association with membranes.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat

Reference	1. Benvenuto, G., Li, S., Brown, S. J., Braverman, R., Vass, W. C., Cheadle, J. P., Halley, D. J. J., Sampson, J. R., Wienecke, R., DeClue, J. E. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19: 6306-6316, 2000. 2. Choi, Y.-J., Di Nardo, A., Kramvis, I., Meikle, L., Kwiatkowski, D. J., Sahin, M., He, X. Tuberous sclerosis complex proteins control axon formation. Genes Dev. 22: 2485-2495, 2008. 3. Tapon, N., Ito, N., Dickson, B. J., Treisman, J. E., Hariharan, I. K. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105: 345-355, 2001.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000026-1	PB9120	100 ug	-	$370		Add to Cart
BHA21000026-3	PB9120-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000026-4	PB9120-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000026-5	PB9120-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000026-6	PB9120-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000026-7	PB9120-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000026-8	PB9120-FITC	100 ug	FITC	$570		Add to Cart
BHA21000026-9	PB9120-HRP	100 ug	HRP	$570		Add to Cart
BHA21000026-10	PB9120-APC	100 ug	APC	$670		Add to Cart
BHA21000026-11	PB9120-PE	100 ug	PE	$670		Add to Cart
BHA21000026-12	PB9120-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000026-13	PB9120-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000026-2	PB9120-10ug	10 ug	Sample	$99		Add to Cart

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