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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GTPase HRAS Antibody Picoband®

SKU : BHA21001092

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Mfr.No.	A00114, A00114-10ug, A00114-Biotin, A00114-Cy3, A00114-Dylight488, A00114-Dylight550, A00114-Dylight594, A00114-FITC, A00114-HRP, A00114-APC, A00114-PE, A00114-iFluor647, A00114-carrier-free
Alternative Names	GTPase HRas
Background	GTPase HRas, also known as transforming protein p21, is an enzyme that in humans is encoded by the HRAS gene. This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-GTPase HRAS Antibody Picoband® catalog # A00114. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human GTPase HRAS, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	21 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	GTPase HRas;H-Ras-1;Ha-Ras;Transforming protein p21;c-H-ras;p21ras;GTPase HRas, N-terminally processed;HRAS;HRAS1;
Tissue Specificity	Widely expressed. .
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P01112
Gene Id	3265
Gene Name	HRAS
Subcellular Location	Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. "Entrez Gene: v-Ha-ras Harvey rat sarcoma viral oncogene homolog".<br /><br />2. Russell MW, Munroe DJ, Bric E, Housman DE, Dietz-Band J, Riethman HC, Collins FS, Brody LC (July 1996). "A 500-kb physical map and contig from the Harvey ras-1 gene to the 11p telomere". Genomics 35 (2): 35360. <br /><br />3. Wong-Staal F, Dalla-Favera R, Franchini G, Gelmann EP, Gallo RC (July 1981). "Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses". Science 213 (4504): 2268. <br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001092-1	A00114	100 ug	-	$370		Add to Cart
BHA21001092-2	A00114-10ug	10 ug	Sample	$99		Add to Cart
BHA21001092-3	A00114-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001092-4	A00114-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001092-5	A00114-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001092-6	A00114-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001092-7	A00114-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001092-8	A00114-FITC	100 ug	FITC	$570		Add to Cart
BHA21001092-9	A00114-HRP	100 ug	HRP	$570		Add to Cart
BHA21001092-10	A00114-APC	100 ug	APC	$670		Add to Cart
BHA21001092-11	A00114-PE	100 ug	PE	$670		Add to Cart
BHA21001092-12	A00114-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001092-13	A00114-carrier-free	100 ug	carrier-free	$370		Add to Cart

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