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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GSDMD Antibody Picoband®

SKU : BHA21002753

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Mfr.No.	A02842, A02842-10ug, A02842-Biotin, A02842-Cy3, A02842-Dylight488, A02842-Dylight550, A02842-Dylight594, A02842-FITC, A02842-HRP, A02842-APC, A02842-PE, A02842-iFluor647, A02842-carrier-free
Alternative Names	Melanocortin receptor 3
Background	Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alteatively spliced transcript variants have been described.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-GSDMD Antibody Picoband® catalog # A02842. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory pattes of activity and wakefulness during periods of limited nutrient availability and f
Host	Rabbit
Immunogen Region	E.coli-derived human GSDMD recombinant protein (Position: M1-H484).
Isotype	Rabbit IgG
Molecular Weight	30, 53 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	gasdermin D, gasdermin-D
Tissue Specificity	Brain, placental, and gut tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P57764
Gene Id	79792
Gene Name	GSDMD
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IF, IHC, ICC, WB, Flow Cytometry
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry(Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Ruhl, S., Shkarina, K., Demarco, B., Heilig, R., Santos, J. C., Broz, P. ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation. Science 362: 956-960, 2018.<br /><br />2. Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., Shao, F. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526: 660-665, 2015. <br /><br />3. Zhu, Q., Zheng, M., Balakrishnan, A., Karki, R., Kanneganti, T.-D. Gasdermin D promotes AIM2 inflammasome activation and is required for host protection against Francisella novicida. J. Immun. 201: 3662-3668, 2018.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002753-1	A02842	-	100 ug	$370		Add to Cart
BHA21002753-2	A02842-10ug	Sample	10 ug	$99		Add to Cart
BHA21002753-3	A02842-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002753-4	A02842-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002753-5	A02842-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002753-6	A02842-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002753-7	A02842-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002753-8	A02842-FITC	FITC	100 ug	$570		Add to Cart
BHA21002753-9	A02842-HRP	HRP	100 ug	$570		Add to Cart
BHA21002753-10	A02842-APC	APC	100 ug	$670		Add to Cart
BHA21002753-11	A02842-PE	PE	100 ug	$670		Add to Cart
BHA21002753-12	A02842-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002753-13	A02842-carrier-free	carrier-free	100 ug	$370		Add to Cart

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