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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GRB7 Antibody Picoband®

SKU : BHA21002833

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Mfr.No.	A02528, A02528-10ug, A02528-Biotin, A02528-Cy3, A02528-Dylight488, A02528-Dylight550, A02528-Dylight594, A02528-FITC, A02528-HRP, A02528-APC, A02528-PE, A02528-iFluor647, A02528-carrier-free
Alternative Names	CD244 molecule
Background	GRB7, growth factor receptor-bound protein 7, is a protein which in humans is encoded by the GRB7 gene. The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alteative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date. GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene. These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7 though to be involved in migration, is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-GRB7 Antibody Picoband® catalog # A02528. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Modulate other receptor-ligand interactions to enhance leukocyte activation.
Host	Rabbit
Immunogen Region	E.coli-derived human GRB7 recombinant protein (Position: R29-S256).
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human, Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Natural killer cell receptor 2B4; Cd244; LOC685808
Tissue Specificity	Expressed in natural killer (NK) cells, T cells and dendritic cells.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q14451
Gene Id	2886
Gene Name	GRB7
Subcellular Location	integral component of membrane

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Tanaka, S., Mori, M., Akiyoshi, T., Tanaka, Y., Mafune, K., Wands, J. R., Sugimachi, K.A novel variant of human Grb7 is associated with invasive esophageal carcinoma.J. Clin. Invest. 102: 821-827, 1998.<br /><br />2. Vayssiere, B., Zalcman, G., Mahe, Y., Mirey, G., Ligensa, T., Weidner, K. M., Chardin, P., Camonis, J.Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family.FEBS Lett. 467: 91-96, 2000.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002833-1	A02528	-	100 ug	$370		Add to Cart
BHA21002833-2	A02528-10ug	Sample	10 ug	$99		Add to Cart
BHA21002833-3	A02528-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002833-4	A02528-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002833-5	A02528-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002833-6	A02528-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002833-7	A02528-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002833-8	A02528-FITC	FITC	100 ug	$570		Add to Cart
BHA21002833-9	A02528-HRP	HRP	100 ug	$570		Add to Cart
BHA21002833-10	A02528-APC	APC	100 ug	$670		Add to Cart
BHA21002833-11	A02528-PE	PE	100 ug	$670		Add to Cart
BHA21002833-12	A02528-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002833-13	A02528-carrier-free	carrier-free	100 ug	$370		Add to Cart

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