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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GRB7 Antibody Picoband®

SKU : BHA21007462

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Mfr.No.	PA1589-1, PA1589-1-10ug, PA1589-1-Biotin, PA1589-1-Cy3, PA1589-1-Dylight488, PA1589-1-Dylight550, PA1589-1-Dylight594, PA1589-1-FITC, PA1589-1-HRP, PA1589-1-APC, PA1589-1-PE, PA1589-1-iFluor647, PA1589-1-carrier-free
Alternative Names	Growth factor receptor-bound protein 7
Background	GRB7, growth factor receptor-bound protein 7, is a protein which in humans is encoded by the GRB7 gene. The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alteative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date. GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene. These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7 thought to be involved in migration, is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-GRB7 Antibody catalog # PA1589-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human GRB7, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Growth factor receptor-bound protein 7;B47;Epidermal growth factor receptor GRB-7;GRB7 adapter protein;GRB7;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q14451
Gene Id	2886
Gene Name	GRB7
Sequence	Belongs to the GRB7/10/14 family.
Subcellular Location	Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule . Cell projection. Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Tanaka, S., Mori, M., Akiyoshi, T., Tanaka, Y., Mafune, K., Wands, J. R., Sugimachi, K.A novel variant of human Grb7 is associated with invasive esophageal carcinoma.J. Clin. Invest. 102: 821-827, 1998.<br /><br />2. Vayssiere, B., Zalcman, G., Mahe, Y., Mirey, G., Ligensa, T., Weidner, K. M., Chardin, P., Camonis, J.Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family.FEBS Lett. 467: 91-96, 2000.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007462-1	PA1589-1	-	100 ug	$370		Add to Cart
BHA21007462-2	PA1589-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21007462-3	PA1589-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007462-4	PA1589-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007462-5	PA1589-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007462-6	PA1589-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007462-7	PA1589-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007462-8	PA1589-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21007462-9	PA1589-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21007462-10	PA1589-1-APC	APC	100 ug	$670		Add to Cart
BHA21007462-11	PA1589-1-PE	PE	100 ug	$670		Add to Cart
BHA21007462-12	PA1589-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007462-13	PA1589-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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