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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Granzyme A/GZMA Antibody Picoband®

SKU : BHA21006908

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Mfr.No.	PA1588, PA1588-10ug, PA1588-Biotin, PA1588-Cy3, PA1588-Dylight488, PA1588-Dylight550, PA1588-Dylight594, PA1588-FITC, PA1588-HRP, PA1588-APC, PA1588-PE, PA1588-iFluor647, PA1588-carrier-free
Alternative Names	Granzyme A
Background	Granzyme A is a protein that in humans is encoded by the GZMA gene. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are though to protect their host by lysing cells bearing on their surface "nonself" antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. GZMA induces caspase-independent apoptosis in a characteristic manner, except it causes a distinctive form of DNA damage: single-stranded DNA nicking. A target of GZMA is the SET complex, including HMGB2 and ANP32A .
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Granzyme A/GZMA Antibody catalog # PA1588. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after L
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Granzyme A.
Isotype	Rabbit IgG
Molecular Weight	22-26 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Granzyme A;3.4.21.78;CTL tryptase;Cytotoxic T-lymphocyte proteinase 1;Fragmentin-1;Granzyme-1;Hanukkah factor;H factor;HF;GZMA;CTLA3, HFSP;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P12544
Gene Name	GZMA
Sequence	Belongs to the peptidase S1 family. Granzyme subfamily.
Subcellular Location	Isoform alpha: Secreted. Cytoplasmic granule.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Fan, Z., Beresford, P. J., Oh, D. Y., Zhang, D., Lieberman, J.Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.Cell 112: 659-672, 2003. Note: Erratum: Cell 115: 241 only, 2003.<br /><br />2. Fink, T. M., Lichter, P., Wekerle, H., Zimmer, M., Jenne, D. E.The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily.Genomics 18: 401-403, 1993.<br /><br />3. Martinvalet, D., Dykxhoo, D. M., Ferrini, R., Lieberman, J.Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.Cell 133: 681-692, 2008.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006908-1	PA1588	-	100 ug	$370		Add to Cart
BHA21006908-2	PA1588-10ug	Sample	10 ug	$99		Add to Cart
BHA21006908-3	PA1588-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006908-4	PA1588-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006908-5	PA1588-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006908-6	PA1588-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006908-7	PA1588-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006908-8	PA1588-FITC	FITC	100 ug	$570		Add to Cart
BHA21006908-9	PA1588-HRP	HRP	100 ug	$570		Add to Cart
BHA21006908-10	PA1588-APC	APC	100 ug	$670		Add to Cart
BHA21006908-11	PA1588-PE	PE	100 ug	$670		Add to Cart
BHA21006908-12	PA1588-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006908-13	PA1588-carrier-free	carrier-free	100 ug	$370		Add to Cart

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