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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GPR2/CCR10 Antibody Picoband®

SKU : BHA21006836

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Mfr.No.	PA1491, PA1491-10ug, PA1491-Biotin, PA1491-Cy3, PA1491-Dylight488, PA1491-Dylight550, PA1491-Dylight594, PA1491-FITC, PA1491-HRP, PA1491-APC, PA1491-PE, PA1491-iFluor647, PA1491-carrier-free
Alternative Names	C-C chemokine receptor type 10
Background	CCR10, C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene. CCR10 is constitutively expressed in skin melanocytes, fibroblasts, and microvascular endothelial cells, and that it is upregulated by IL1B and TNF. Expression was also detected in T cells, Langerhans cells, and peripheral blood mononuclear cells but not in dendritic cells.By fluorescence in situ hybridization, the GPR2 gene is mapped to 17q21.1-q21.3. CCR10 is the receptor for CCL27. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation. expression of CCL27 in normal keratinocytes and its strong upregulation in skin lesions of atopic dermatitis, contact dermatitis, and psoriasis patients. CCR10+ T lymphocytes were detected in lesional but not normal skin of these patients. Flow cytometric analysis showed that CCL27 binds extracellular matrix components and dermal microvascular endothelial cells and fibroblasts and mediates adhesion and transendothelial migration of CCR10+ circulating leukocytes. CCR10 is predominantly expressed on CD4+CLA+ (cutaneous lymphocyte antigen), rather than CD8+, circulating T cells. RT-PCR, confocal microscopy, and ELISA analysis indicated that keratinocytes exposed to TNF or IL1B but not to IL4 or IFNG in vitro express increased CCL27.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-GPR2/CCR10 Antibody catalog # PA1491. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human GPR2/CCR10, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	20 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	C-C chemokine receptor type 10;C-C CKR-10;CC-CKR-10;CCR-10;G-protein coupled receptor 2;CCR10;GPR2;
Tissue Specificity	Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P46092
Gene Name	CCR10
Sequence	Belongs to the G-protein coupled receptor 1 family.
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Homey, B., Alenius, H., Muller, A., Soto, H., Bowman, E. P., Yuan, W., McEvoy, L., Lauerma, A. I., Assmann, T., Bunemann, E., Lehto, M., Wolff, H., Yen, D., Marxhausen, H., To, W., Sedgwick, J., Ruzicka, T., Lehmann, P., Zlotnik, A.CCL27-CCR10 interactions regulate T cell-mediated skin inflammation.Nature Med. 8: 157-165, 2002.<br /><br />2. Jarmin, D. I., Rits, M., Bota, D., Gerard, N. P., Graham, G. J., Clark-Lewis, I., Gerard, C.Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine.J. Immun. 164: 3460-3464, 2000.<br /><br />3. Marchese, A., Docherty, J. M., Nguyen, T., Heiber, M., Cheng, R., Heng, H. H. Q., Tsui, L.-C., Shi, X., George, S. R., O'Dowd, B. F.Cloning of human genes encoding novel G protein-coupled receptors.Genomics 23: 609-618, 1994.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006836-1	PA1491	-	100 ug	$370		Add to Cart
BHA21006836-2	PA1491-10ug	Sample	10 ug	$99		Add to Cart
BHA21006836-3	PA1491-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006836-4	PA1491-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006836-5	PA1491-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006836-6	PA1491-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006836-7	PA1491-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006836-8	PA1491-FITC	FITC	100 ug	$570		Add to Cart
BHA21006836-9	PA1491-HRP	HRP	100 ug	$570		Add to Cart
BHA21006836-10	PA1491-APC	APC	100 ug	$670		Add to Cart
BHA21006836-11	PA1491-PE	PE	100 ug	$670		Add to Cart
BHA21006836-12	PA1491-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006836-13	PA1491-carrier-free	carrier-free	100 ug	$370		Add to Cart

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