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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GPR17 Antibody

SKU : BHA21300464

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Alomone Labs

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Mfr.No.	AGR-048, AGR-048-CF_0.2 ml, AGR-048_0.2 ml, AGR-048_25 mcl, AGR-048_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	GPR17 is an orphan receptor that can be double-activated by uracil and cysteinyl-leukotriene (CysLT). It is phylogenetically related to both purinergic P2Y and CysLT receptors. GPR17 belongs to the superfamily of G-protein coupled receptors (GPCRs)4.GPR17 expression is highly detected in the brain, kidney, and heart. In the brain, GPR17 is mainly distributed in white matter, gray matter, subependymal zone, and corpus callosum1.Studies have shown that GPR17 receptor plays an important role in spinal cord injury, myelin sheath injury, cerebral ischemic injury, where its expression is extremely upregulated1,2.GPR17 activation promotes oligodendrocyte differentiation and progression toward mature myelin-forming cells. Thus, GPR17 modulators may be used as therapeutic tools to treat pathologies associated with myelin repair in CNS demyelinating diseases3.
Clonality	Polyclonal
Description	Anti-GPR17 Antibody (#AGR-048) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GPR17 from rat and mouse samples. It is unlikely to recognize the protein from human samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	Intracellular, 3rd loop
Isotype	Rabbit IgG
Reactivity	Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	G-protein coupled receptor 17, Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT Receptor, P2Y-like receptor
UNSPSC Code	41116161
Note	Homology: Mouse - identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-GR048 Specifictiy: GPR17 AB Specifictiy: Not recommended for human samples. Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	Q09QM4
Gene Id	767613
Target	G-protein coupled receptor 17, Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT Receptor, P2Y-like receptor
Sequence	(C)RQGPRIEKHLKNK, corresponding to amino acid residues 220-232 of rat GPR17

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IF, IHC, WB
Dilution	Immunohistochemistry paraffin embedded sections ihc: 1:300 Western blot wb: 1:200

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300464-1	AGR-048-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21300464-2	AGR-048_0.2 ml	0.2 ml	$795		Add to Cart
BHA21300464-3	AGR-048_25 mcl	25 mcl	$597		Add to Cart
BHA21300464-4	AGR-048_50 mcl	50 mcl	$697		Add to Cart

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