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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GJB2 Antibody Picoband®

SKU : BHA21004039

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Mfr.No.	A00512-2, A00512-2-10ug, A00512-2-Biotin, A00512-2-Cy3, A00512-2-Dylight488, A00512-2-Dylight550, A00512-2-Dylight594, A00512-2-FITC, A00512-2-HRP, A00512-2-APC, A00512-2-PE, A00512-2-iFluor647, A00512-2-carrier-free
Alternative Names	cyclin-dependent kinase 5
Background	Connexin26(CX26), also known as GAP junction protein, beta2, GJB2. Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The 3-prime untranslated region of the CX26 transcript contains a putative mRNA instability sequence. The deduced 226-amino acid protein has a calculated molecular mass of about 26 kD. CX26 shares 92.5% identity with rat Cx26. connexin 26(GJB2) is assigned to human chromosome 13q11-q12 .Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. Connexin 26 gene(GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-GJB2 Antibody Picoband® catalog # A00512-2. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Proline-ed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human GJB2, which shares 82.4% amino acid (aa) sequence identity with mouse and rat GJB2.
Isotype	Rabbit IgG
Molecular Weight	26 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Cyclin-dependent-like kinase 5; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit; CDK5; CDKN5
Tissue Specificity	Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P29033
Gene Id	2706
Gene Name	GJB2
Subcellular Location	Cell membrane. Peripheral membrane protein. Postsynaptic density. Cytoplasm. Perikaryon. Lamellipodium. Growth cone.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Mignon, C.; Fromaget, C.; Mattei, M.-G.; Gros, D.; Yamasaki, H.; Mesnil, M. : Assignment of connexin 26 (GJB2) and 46 (GJA3) genes to human chromosome 13q11-q12 and mouse chromosome 14D1-E1 by in situ hybridization. Cytogenet. Cell Genet. 72: 185-186, 1996. <br /><br />2. Djalilian, A. R.; McGaughey, D.; Patel, S.; Seo, E. Y.; Yang, C.; Cheng, J.; Tomic, M.; Sinha, S.; Ishida-Yamamoto, A.; Segre, J. A. : Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J. Clin. Invest. 116: 1243-1253, 2006. <br /><br />3. Abe, S.; Kelley, P. M.; Kimberling, W. J.; Usami, S. : Connexin 26 gene (GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation. Am. J. Med. Genet. 103: 334-338, 2001.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004039-1	A00512-2	-	100 ug	$370		Add to Cart
BHA21004039-2	A00512-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004039-3	A00512-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004039-4	A00512-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004039-5	A00512-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004039-6	A00512-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004039-7	A00512-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004039-8	A00512-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004039-9	A00512-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004039-10	A00512-2-APC	APC	100 ug	$670		Add to Cart
BHA21004039-11	A00512-2-PE	PE	100 ug	$670		Add to Cart
BHA21004039-12	A00512-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004039-13	A00512-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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