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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GIP Antibody Picoband®

SKU : BHA21000847

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Mfr.No.	PB9947, PB9947-10ug, PB9947-Biotin, PB9947-Cy3, PB9947-Dylight488, PB9947-Dylight550, PB9947-Dylight594, PB9947-FITC, PB9947-HRP, PB9947-APC, PB9947-PE, PB9947-iFluor647, PB9947-carrier-free
Alternative Names	Gastric inhibitory polypeptide
Background	Gastric inhibitory polypeptide (GIP), also known as the glucose-dependent insulinotropic peptide, is an inhibiting hormone of the secretin family of hormones. GIP is thought to have significant effects on fatty acid metabolism through stimulation of lipoprotein lipase activity in adipocytes. Additionally, GIP release has been demonstrated in the ruminant animal and may play a role in nutrient partitioning in milk production (lipid metabolism). Recently, GIP appeared as a major player in bone remodelling. It was evidenced that genetic ablation of the GIP receptor in mice resulted in profound alterations of bone microarchitecture through modification of the adipokine network. Furthermore, the deficiency in GIP receptors has also been associated in mice with a dramatic decrease in bone quality and a subsequent increase in fracture risk.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-GIP Antibody Picoband® catalog # PB9947. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
Host	Rabbit
Immunogen Region	E. coli-derived mouse GIP recombinant protein (Position: Y44-Q85). Mouse GIP shares 92.9% amino acid (aa) sequence identity with both human and rat GIP.
Isotype	Rabbit IgG
Molecular Weight	18 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Gastric inhibitory polypeptide;GIP;Glucose-dependent insulinotropic polypeptide;Gip;
Tissue Specificity	Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P48756
Gene Id	14607
Gene Name	Gip
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse Immunohistochemistry, 2-5 ug/ml, Mouse, Rat

Reference	1. Gaudin-Audrain C, Irwin N, Mansur S, Flatt PR, Thorens B, Baslé M, Chappard D, Mabilleau G (Mar 2013). "Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice". Bone 53 (1): 22130. 2. Mieczkowska A, Irwin N, Flatt PR, Chappard D, Mabilleau G (Oct 2013). "Glucose-dependent insulinotropic polypeptide (GIP) receptor deletion leads to reduced bone strength and quality".Bone 56 (2): 33742.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000847-1	PB9947	100 ug	-	$370		Add to Cart
BHA21000847-2	PB9947-10ug	10 ug	Sample	$99		Add to Cart
BHA21000847-3	PB9947-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000847-4	PB9947-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000847-5	PB9947-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000847-6	PB9947-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000847-7	PB9947-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000847-8	PB9947-FITC	100 ug	FITC	$570		Add to Cart
BHA21000847-9	PB9947-HRP	100 ug	HRP	$570		Add to Cart
BHA21000847-10	PB9947-APC	100 ug	APC	$670		Add to Cart
BHA21000847-11	PB9947-PE	100 ug	PE	$670		Add to Cart
BHA21000847-12	PB9947-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000847-13	PB9947-carrier-free	100 ug	carrier-free	$370		Add to Cart

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