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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Ghrelin/GHRL Antibody

SKU : BHA21004075

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Mfr.No.	A01710-2, A01710-2-10ug, A01710-2-Biotin, A01710-2-Cy3, A01710-2-Dylight488, A01710-2-Dylight550, A01710-2-Dylight594, A01710-2-FITC, A01710-2-HRP, A01710-2-APC, A01710-2-PE, A01710-2-iFluor647, A01710-2-carrier-free
Alternative Names	fibroblast growth factor 10
Background	This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alteative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Ghrelin/GHRL Antibody Picoband® catalog # A01710-2. Tested in IHC applications. This antibody reacts with Human.
Function	Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Ghrelin/GHRL, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	20 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Fibroblast growth factor 10; FGF-10; Keratinocyte growth factor 2; FGF10
Tissue Specificity	Expressed in numerous tissues with highest level in testis.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9UBU3
Gene Id	51738
Gene Name	GHRL
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	IHC
Description	Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br>

Reference	1. Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschop, M. H., Gao, X.-B., Horvath, T. L. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116: 3229-3239, 2006. <br /><br />2. Andrews, Z. B., Liu, Z.-W., Wallingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschop, M. H., Shanabrough, M., Cline, G., Shulman, G. I., Coppola, A., Gao, X.-B., Horvath, T. L., Diano, S. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 454: 846-851, 2008. Note: Erratum: Nature 459: 736 only, 2009.<br /><br />3. Chartrel, N., Alvear-Perez, R., Leprince, J., Iturrioz, X., Reaux-Le Goazigo, A., Audinot, V., Chomarat, P., Coge, F., Nosjean, O., Rodriguez, M., Galizzi, J. P., Boutin, J. A., Vaudry, H., Llorens-Cortes, C. Comment on 'Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.' Science 315: 766 only, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004075-1	A01710-2	-	100 ug	$370		Add to Cart
BHA21004075-2	A01710-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004075-3	A01710-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004075-4	A01710-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004075-5	A01710-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004075-6	A01710-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004075-7	A01710-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004075-8	A01710-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004075-9	A01710-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004075-10	A01710-2-APC	APC	100 ug	$670		Add to Cart
BHA21004075-11	A01710-2-PE	PE	100 ug	$670		Add to Cart
BHA21004075-12	A01710-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004075-13	A01710-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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