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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GCLC Antibody Picoband®

SKU : BHA21006837

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Mfr.No.	PA1492, PA1492-10ug, PA1492-Biotin, PA1492-Cy3, PA1492-Dylight488, PA1492-Dylight550, PA1492-Dylight594, PA1492-FITC, PA1492-HRP, PA1492-APC, PA1492-PE, PA1492-iFluor647, PA1492-carrier-free
Alternative Names	Glutamate--cysteine ligase catalytic subunit
Background	GCLC, Glutamate--cysteine ligase catalytic subunit, is an enzyme that in humans is encoded by the GCLC gene. Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6p12.1. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-GCLC Antibody catalog # PA1492. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human GCLC, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	20 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Glutamate--cysteine ligase catalytic subunit;6.3.2.2;GCS heavy chain;Gamma-ECS;Gamma-glutamylcysteine synthetase;GCLC;GLCL, GLCLC;
Tissue Specificity	Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P48506
Gene Name	GCLC
Sequence	Belongs to the glutamate--cysteine ligase type 3 family.
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Rat, Human, Mouse<br>

Reference	1. Gipp, J. J., Chang, C., Mulcahy, R. T.Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetase.Biochem. Biophys. Res. Commun. 185: 29-35, 1992.<br /><br />2. Sierra-Rivera, E., Summar, M. L., Dasouki, M., Krishnamani, M. R. S., Phillips, J. A., Freeman, M. L.Assignment of the gene (GLCLC) that encodes the heavy subunit of gamma-glutamylcysteine synthetase to human chromosome 6.Cytogenet. Cell Genet. 70: 278-279, 1995.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006837-1	PA1492	-	100 ug	$370		Add to Cart
BHA21006837-2	PA1492-10ug	Sample	10 ug	$99		Add to Cart
BHA21006837-3	PA1492-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006837-4	PA1492-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006837-5	PA1492-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006837-6	PA1492-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006837-7	PA1492-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006837-8	PA1492-FITC	FITC	100 ug	$570		Add to Cart
BHA21006837-9	PA1492-HRP	HRP	100 ug	$570		Add to Cart
BHA21006837-10	PA1492-APC	APC	100 ug	$670		Add to Cart
BHA21006837-11	PA1492-PE	PE	100 ug	$670		Add to Cart
BHA21006837-12	PA1492-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006837-13	PA1492-carrier-free	carrier-free	100 ug	$370		Add to Cart

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