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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GABA Transporter 1/GAT 1/SLC6A1 Antibody Picoband®

SKU : BHA21007007

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Mfr.No.	PA1721, PA1721-10ug, PA1721-Biotin, PA1721-Cy3, PA1721-Dylight488, PA1721-Dylight550, PA1721-Dylight594, PA1721-FITC, PA1721-HRP, PA1721-APC, PA1721-PE, PA1721-iFluor647, PA1721-carrier-free
Alternative Names	Sodium- and chloride-dependent GABA transporter 1
Background	GABA transporter 1 (GAT1), also known as sodium- and chloride-dependent GABA transporter 1, is a protein that in humans is encoded by the SLC6A1 gene. GABA Transporter 1 uses Na+ and Cl- to create a gradient, which removes or adds GABA to extracellular spaces in the cerebrum and cerebellum. The stoichiometry for GABA Transporter 1 is 2 Na+: 1 Cl-: 1 GABA. The activity of GAT1 is largely dependent on the presence of Na+, while Cl- assists by increasing the ability for GAT-1 to uptake GABA.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-GABA Transporter 1/GAT 1/SLC6A1 Antibody catalog # PA1721. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human GABA Transporter 1, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	29 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Sodium- and chloride-dependent GABA transporter 1;GAT-1;Solute carrier family 6 member 1;SLC6A1;GABATR, GABT1, GAT1;
Tissue Specificity	Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P30531
Gene Name	SLC6A1
Sequence	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of inteeurons (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Rat, Human, Mouse , By Heat<br>Weste blot, 0.1-0.5ug/ml, Mouse, Rat, Human<br>

Reference	1. Carvill, G. L., McMahon, J. M., Schneider, A., Zemel, M., Myers, C. T., Saykally, J., Nguyen, J., Robbiano, A., Zara, F., Specchio, N., Mecarelli, O., Smith, R. L., and 13 others. Mutations in the GABA transporter SLC6A1 cause epilepsy with myoclonic-atonic seizures. Am. J. Hum. Genet. 96: 808-815, 2015. Huang, F., Shi, L. J.,<br /><br />2. Cope, D. W., Di Giovanni, G., Fyson, S. J., Orban, G., Errington, A. C., Lorincz, M. L., Gould, T. M., Carter, D. A., Crunelli, V. Enhanced tonic GABA-A inhibition in typical absence epilepsy. Nature Med. 15: 1392-1398, 2009. <br /><br />3. Heng, H. H. Q., Fei, J., Guo, L.-H. Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25. Genomics 29: 302-304, 1995. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007007-1	PA1721	-	100 ug	$370		Add to Cart
BHA21007007-2	PA1721-10ug	Sample	10 ug	$99		Add to Cart
BHA21007007-3	PA1721-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007007-4	PA1721-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007007-5	PA1721-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007007-6	PA1721-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007007-7	PA1721-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007007-8	PA1721-FITC	FITC	100 ug	$570		Add to Cart
BHA21007007-9	PA1721-HRP	HRP	100 ug	$570		Add to Cart
BHA21007007-10	PA1721-APC	APC	100 ug	$670		Add to Cart
BHA21007007-11	PA1721-PE	PE	100 ug	$670		Add to Cart
BHA21007007-12	PA1721-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007007-13	PA1721-carrier-free	carrier-free	100 ug	$370		Add to Cart

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