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Home / Primary Antibodies / Polyclonal Antibodies

Anti-G-protein coupled receptor 30/GPER1 Antibody Picoband®

SKU : BHA21007414

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Mfr.No.	PA2235, PA2235-10ug, PA2235-Biotin, PA2235-Cy3, PA2235-Dylight488, PA2235-Dylight550, PA2235-Dylight594, PA2235-FITC, PA2235-HRP, PA2235-APC, PA2235-PE, PA2235-iFluor647, PA2235-carrier-free
Alternative Names	G-protein coupled estrogen receptor 1
Background	G-protein coupled estrogen receptor 1 (GPER1), also known as the GPR30 or CEPR is a G protein-coupled receptor that in humans is encode d by the GPER gene. This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. It is mapped to 7p22.3. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alteate transcriptional splice variants which encode the same protein have been characterized.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-G-protein coupled receptor 30/GPER1 Antibody catalog # PA2235. Tested in WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	G-protein coupled estrogen receptor that binds to 17- beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human G-protein coupled receptor 30, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human, Monkey
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	G-protein coupled estrogen receptor 1;Chemoattractant receptor-like 2;Flow-induced endothelial G-protein coupled receptor 1;FEG-1;G protein-coupled estrogen receptor 1;G-protein coupled receptor 30;GPCR-Br;IL8-related receptor DRY12;Lymphocyte-derived G-protein coupled receptor;LYGPR;Membrane estrogen receptor;mER;GPER1;CEPR, CMKRL2, DRY12, GPER, GPR30;
Tissue Specificity	Expressed in placenta, endothelial and epithelial cells, non laboring and laboring term myometrium, fibroblasts and cancer-associated fibroblasts (CAF), prostate cancer cells and invasive adenocarcinoma (at protein level). Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q99527
Gene Name	GPER1
Sequence	Belongs to the G-protein coupled receptor 1 family.
Subcellular Location	Nucleus. Cytoplasm . Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Multi- pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus membrane ; Multi-pass membrane protein . Golgi apparatus, trans-Golgi network. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite . Cell projection, dendritic spine membrane ; Multi-pass membrane protein . Cell projection, axon . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Mitochondrion membrane ; Multi-pass membrane protein . Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes (By similarity). Endocytosed in a agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane. Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum. Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer-associated fibroblasts (CAF). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Monkey<br>

Reference	1. Pietras, R. J., Levin, E. R., Szego, C. M. Estrogen receptors and cell signaling. (Letter)Science 310: 51-52, 2005.<br /><br />2. Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterbu, J. B., Prossnitz, E. R. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307: 1625-1630, 2005. <br /><br />3. Takada, Y., Kato, C., Kondo, S., Korenaga, R., Ando, J. Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress. Biochem. Biophys. Res. Commun. 240: 737-741, 1997.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007414-1	PA2235	-	100 ug	$370		Add to Cart
BHA21007414-2	PA2235-10ug	Sample	10 ug	$99		Add to Cart
BHA21007414-3	PA2235-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007414-4	PA2235-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007414-5	PA2235-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007414-6	PA2235-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007414-7	PA2235-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007414-8	PA2235-FITC	FITC	100 ug	$570		Add to Cart
BHA21007414-9	PA2235-HRP	HRP	100 ug	$570		Add to Cart
BHA21007414-10	PA2235-APC	APC	100 ug	$670		Add to Cart
BHA21007414-11	PA2235-PE	PE	100 ug	$670		Add to Cart
BHA21007414-12	PA2235-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007414-13	PA2235-carrier-free	carrier-free	100 ug	$370		Add to Cart

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