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Home / Primary Antibodies / Polyclonal Antibodies

Anti-FXI/F11 Antibody Picoband®

SKU : BHA21003786

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Mfr.No.	A00989-1, A00989-1-10ug, A00989-1-Biotin, A00989-1-Cy3, A00989-1-Dylight488, A00989-1-Dylight550, A00989-1-Dylight594, A00989-1-FITC, A00989-1-HRP, A00989-1-APC, A00989-1-PE, A00989-1-iFluor647, A00989-1-carrier-free
Alternative Names	Purine nucleoside phosphorylase
Background	Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene. This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an inteal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-FXI/F11 Antibody Picoband® catalog # A00989-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. .
Host	Rabbit
Immunogen Region	E.coli-derived human FXI/F11 recombinant protein (Position: K79-Q155).
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Purine nucleoside phosphorylase;PNP;2.4.2.1;Inosine phosphorylase;Inosine-guanosine phosphorylase;PNP;NP;
Tissue Specificity	Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P03951
Gene Id	2160
Gene Name	F11
Subcellular Location	Cytoplasm, cytoskeleton . Cytoplasm .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.1-0.25 ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Asakai, R., Chung, D. W., Davie, E. W., Seligsohn, U. Factor XI deficiency in Ashkenazi Jews in Israel. New Eng. J. Med. 325: 153-158, 1991. 2. Asakai, R., Chung, D. W., Ratnoff, O. D., Davie, E. W. Factor XI (plasma thromboplastin antecedent) deficiency in Ashkenazi Jews is a bleeding disorder that can result from three types of point mutations. Proc. Nat. Acad. Sci. 86: 7667-7671, 1989. 3. Asakai, R., Davie, E. W., Chung, D. W. Organization of the gene for human factor XI. Biochemistry 26: 7221-7228, 1987.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003786-1	A00989-1	-	100 ug	$370		Add to Cart
BHA21003786-2	A00989-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21003786-3	A00989-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003786-4	A00989-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003786-5	A00989-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003786-6	A00989-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003786-7	A00989-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003786-8	A00989-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21003786-9	A00989-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21003786-10	A00989-1-APC	APC	100 ug	$670		Add to Cart
BHA21003786-11	A00989-1-PE	PE	100 ug	$670		Add to Cart
BHA21003786-12	A00989-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003786-13	A00989-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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