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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Forkhead box protein P3 FOXP3 Antibody Picoband®

SKU : BHA21006900

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Mfr.No.	PA1577, PA1577-10ug, PA1577-Biotin, PA1577-Cy3, PA1577-Dylight488, PA1577-Dylight550, PA1577-Dylight594, PA1577-FITC, PA1577-HRP, PA1577-APC, PA1577-PE, PA1577-iFluor647, PA1577-carrier-free
Alternative Names	Forkhead box protein P3
Background	FOXP3 (forkhead box P3) is a protein involved in immune system responses. The human FOXP3 genes contain 11 coding exons. Exon-intron boundaries are identical across the coding regions of the mouse and human genes. By genomic sequence analysis, the FOXP3 gene maps to the p arm of the X chromosome (specifically, Xp11.23). A member of the FOX protein family, FOXP3 appears to function as a master regulator in the development and function of regulatory T cells. While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Forkhead box protein P3 FOXP3 Antibody catalog # PA1577. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stabi
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human FOXP3, different from the related mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Forkhead box protein P3;Scurfin;Forkhead box protein P3, C-terminally processed;Forkhead box protein P3 41 kDa form;FOXP3;IPEX;JM2;
Tissue Specificity	Ubiquitous.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2mg Na2HPO4.

Uniprot	Q9BZS1
Gene Name	FOXP3
Sequence	Contains 1 C2H2-type zinc finger.
Subcellular Location	Nucleus . Cytoplasm . Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Allan, S. E., Passerini, L., Bacchetta, R., Crellin, N., Dai, M., Orban, P. C., Ziegler, S. F., Roncarolo, M. G., Levings, M. K.The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.J. Clin. Invest. 115: 3276-3284, 2005.<br /><br />2. Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E., Saulsbury, F. T., Chance, P. F., Ochs, H. D.The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.Nature Genet. 27: 20-21, 2001.<br /><br />3. Hong, J., Li, N., Zhang, X., Zheng, B., Zhang, J. Z.Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3.Proc. Nat. Acad. Sci. 102: 6449-6454, 2005.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006900-1	PA1577	-	100 ug	$370		Add to Cart
BHA21006900-2	PA1577-10ug	Sample	10 ug	$99		Add to Cart
BHA21006900-3	PA1577-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006900-4	PA1577-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006900-5	PA1577-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006900-6	PA1577-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006900-7	PA1577-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006900-8	PA1577-FITC	FITC	100 ug	$570		Add to Cart
BHA21006900-9	PA1577-HRP	HRP	100 ug	$570		Add to Cart
BHA21006900-10	PA1577-APC	APC	100 ug	$670		Add to Cart
BHA21006900-11	PA1577-PE	PE	100 ug	$670		Add to Cart
BHA21006900-12	PA1577-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006900-13	PA1577-carrier-free	carrier-free	100 ug	$370		Add to Cart

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