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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Flt3/CD135 Antibody Picoband®

SKU : BHA21001306

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Mfr.No.	A00188-4, A00188-4-10ug, A00188-4-Biotin, A00188-4-Cy3, A00188-4-Dylight488, A00188-4-Dylight550, A00188-4-Dylight594, A00188-4-FITC, A00188-4-HRP, A00188-4-APC, A00188-4-PE, A00188-4-iFluor647, A00188-4-carrier-free
Alternative Names	FMS-like tyrosine kinase 3
Background	Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Flt3/CD135 Antibody Picoband® catalog # A00188-4. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activatio
Host	Rabbit
Immunogen Region	E. coli-derived mouse Flt3 / CD135 recombinant protein (Position: E62-E295).
Isotype	Rabbit IgG
Molecular Weight	160 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Receptor-type tyrosine-protein kinase FLT3; 2.7.10.1; FL cytokine receptor; Fetal liver kinase 2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Tyrosine-protein kinase receptor flk-2; CD135; Flt3; Flk-2, Flt-3;
Tissue Specificity	Hematopoietic stem and progenitor cell- enriched populations. Found in brain, placenta and testis.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Flt3: Q00342
Gene Id	14255
Gene Name	Flt3
Subcellular Location	Membrane; Constitutively activated mutant forms with inteal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Verstraete K, Vandriessche G, Januar M, Elegheert J, Shkumatov AV, Desfosses A, Van Craenenbroeck K, Svergun DI, Gutsche I, Vergauwen B, Savvides SN (February 2011). "Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex". Blood. 118 (1): 6068.<br /><br />2. Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Saito K, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Saito H, Ueda R, Ohno R, Naoe T (April 2001). "Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies". Blood. 97 (8): 24349.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001306-1	A00188-4	100 ug	-	$370		Add to Cart
BHA21001306-2	A00188-4-10ug	10 ug	Sample	$99		Add to Cart
BHA21001306-3	A00188-4-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001306-4	A00188-4-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001306-5	A00188-4-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001306-6	A00188-4-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001306-7	A00188-4-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001306-8	A00188-4-FITC	100 ug	FITC	$570		Add to Cart
BHA21001306-9	A00188-4-HRP	100 ug	HRP	$570		Add to Cart
BHA21001306-10	A00188-4-APC	100 ug	APC	$670		Add to Cart
BHA21001306-11	A00188-4-PE	100 ug	PE	$670		Add to Cart
BHA21001306-12	A00188-4-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001306-13	A00188-4-carrier-free	100 ug	carrier-free	$370		Add to Cart

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