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Home / Primary Antibodies / Polyclonal Antibodies

Anti-FKBP52/FKBP4 Antibody Picoband®

SKU : BHA21003949

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Mfr.No.	A02165-3, A02165-3-10ug, A02165-3-Biotin, A02165-3-Cy3, A02165-3-Dylight488, A02165-3-Dylight550, A02165-3-Dylight594, A02165-3-FITC, A02165-3-HRP, A02165-3-APC, A02165-3-PE, A02165-3-iFluor647, A02165-3-carrier-free
Alternative Names	phospholipase A2 group VII
Background	FK506-binding protein 4 is a protein that in humans is encoded by the FKBP4 gene. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-FKBP52/FKBP4 Antibody Picoband® catalog # A02165-3. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phosphol
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human FKBP52/FKBP4, which shares 94.7% amino acid (aa) sequence identity with mouse and rat FKBP4.
Isotype	Rabbit IgG
Molecular Weight	56-59 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Platelet-activating factor acetylhydrolase; PAF acetylhydrolase; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; Group-VIIA phospholipase A2; gVIIA-PLA2; LDL-associated phospholipase A2; LDL-PLA (2); PAF 2-acylhydrolase; PLA2G7; PAFAH
Tissue Specificity	Plasma.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q02790
Gene Id	2288
Gene Name	FKBP4
Subcellular Location	Secreted, extracellular space.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB
Description	Western blot, 0.25-0.5 ug/ml, Human, Mouse, Rat

Reference	1. Chambraud, B., Radanyi, C., Camonis, J. H., Rajkowski, K., Schumacher, M., Baulieu, E.-E. Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-CoA alpha-hydroxylase is a new FKBP-associated protein. Proc. Nat. Acad. Sci. 96: 2104-2109, 1999. 2. Chen, H., Yong, W., Hinds, T. D., Jr., Yang, Z., Zhou, Y., Sanchez, E. R., Shou, W. Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis. J. Biol. Chem. 285: 27776-27784, 2010. 3. Cheung-Flynn, J., Prapapanich, V., Cox, M. B., Riggs, D. L., Suarez-Quian, C., Smith, D. F. Physiological role for the cochaperone FKBP52 in androgen receptor signaling. Molec. Endocr. 19: 1654-1666, 2005.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003949-1	A02165-3	-	100 ug	$370		Add to Cart
BHA21003949-2	A02165-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21003949-3	A02165-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003949-4	A02165-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003949-5	A02165-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003949-6	A02165-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003949-7	A02165-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003949-8	A02165-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21003949-9	A02165-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21003949-10	A02165-3-APC	APC	100 ug	$670		Add to Cart
BHA21003949-11	A02165-3-PE	PE	100 ug	$670		Add to Cart
BHA21003949-12	A02165-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003949-13	A02165-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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