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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Filaggrin/FLG Antibody Picoband®

SKU : BHA21000771

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Mfr.No.	PB9870, PB9870-10ug, PB9870-Biotin, PB9870-Cy3, PB9870-Dylight488, PB9870-Dylight550, PB9870-Dylight594, PB9870-FITC, PB9870-HRP, PB9870-APC, PB9870-PE, PB9870-iFluor647, PB9870-carrier-free
Alternative Names	Filaggrin
Background	In humans, profillagrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21. The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Filaggrin/FLG Antibody Picoband® catalog # PB9870. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Host	Rabbit
Immunogen Region	E. coli-derived human Filaggrin recombinant protein (Position: M1-R261).
Isotype	Rabbit IgG
Molecular Weight	435 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Filaggrin;FLG;
Tissue Specificity	Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland (PubMed:19384417). In the skin, mainly expressed in stratum granulosum of the epidermis (PubMed:1429717) (PubMed:19384417). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P20930
Gene Id	2312
Gene Name	FLG
Subcellular Location	Cytoplasmic granule . In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower coeocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Kypriotou, Magdalini; Huber, Marcel; Hohl, Daniel (September 2012)."The human epidermal differentiation complex: coified envelope precursors, S100 proteins and the fused genes family". Experimental Dermatology 21 (9): 643649. 2. Markova, NG; Marekov, LN; Chipev, CC; Gan, SQ; Idler, WW; Steinert, PM (January 1993). "Profilaggrin is a major epidermal calcium-binding protein.". Molecular and Cellular Biology 13 (1): 61325.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000771-1	PB9870	100 ug	-	$370		Add to Cart
BHA21000771-2	PB9870-10ug	10 ug	Sample	$99		Add to Cart
BHA21000771-3	PB9870-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000771-4	PB9870-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000771-5	PB9870-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000771-6	PB9870-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000771-7	PB9870-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000771-8	PB9870-FITC	100 ug	FITC	$570		Add to Cart
BHA21000771-9	PB9870-HRP	100 ug	HRP	$570		Add to Cart
BHA21000771-10	PB9870-APC	100 ug	APC	$670		Add to Cart
BHA21000771-11	PB9870-PE	100 ug	PE	$670		Add to Cart
BHA21000771-12	PB9870-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000771-13	PB9870-carrier-free	100 ug	carrier-free	$370		Add to Cart

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