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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Fibroblast growth factor 8 FGF8 Antibody Picoband®

SKU : BHA21006684

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Mfr.No.	PA1216, PA1216-10ug, PA1216-Biotin, PA1216-Cy3, PA1216-Dylight488, PA1216-Dylight550, PA1216-Dylight594, PA1216-FITC, PA1216-HRP, PA1216-APC, PA1216-PE, PA1216-iFluor647, PA1216-carrier-free
Alternative Names	Fibroblast growth factor 8
Background	Fibroblast growth factor 8 (androgen-induced), also known as FGF8 or AIGF, is a human gene which maps to 10q24. The protein encoded by this gene are secreted proteins that interact with FGF tyrosine kinase receptors to mediate growth and development. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The temporal and spatial pattes of this gene expression suggest that FGF8 is involved in gastrulation, regionalization of the brain, and organogenesis of the limb and face as an embryonic epithelial factor. The adult expression of FGF8 is restricted to gonads, including testes and ovaries. FGF8 stimulated growth of human prostate carcinoma cells and mouse fibroblasts and mammary carcinoma cells in a dose-dependent manner. It also may play an important role in growth and patteing of limbs, face, and central nervous system. FGF8 is expressed in increased levels in breast cancer and in lactating human breast; it was also detected in human milk. A survey of other normal tissues showed that FGF8 is expressed in the proliferative cells of the skin and epithelial cells in colon, ovary, fallopian tube, and uterus. FGF8 in adults expression is restricted to the gonads. We detected rat ovary in our lab.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Fibroblast growth factor 8 FGF8 Antibody catalog # PA1216. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotr
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human FGF8, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	272 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Fibroblast growth factor 8;FGF-8;Androgen-induced growth factor;AIGF;Heparin-binding growth factor 8;HBGF-8;FGF8;AIGF;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P55075
Gene Name	FGF8
Sequence	Belongs to the heparin-binding growth factors family.
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat <br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Tanaka, A.; Miyamoto, K.; Matsuo, H.; Matsumoto, K.; Yoshida, H. : Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties. FEBS Lett. 363: 226-230, 1995.<br /><br />2. Yoshiura, K.; Leysens, N. J.; Chang, J.; Ward, D.; Murray, J. C.; Muenke, M. : Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes. Am. J. Med. Genet. 72: 354-362, 1997.<br /><br />3. Zammit, C.; Coope, R.; Gomm, J. J.; Shousha, S.; Johnston, C. L.; Coombes, R. C. : Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer. Brit. J. Cancer 86: 1097-1103, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006684-1	PA1216	-	100 ug	$370		Add to Cart
BHA21006684-2	PA1216-10ug	Sample	10 ug	$99		Add to Cart
BHA21006684-3	PA1216-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006684-4	PA1216-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006684-5	PA1216-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006684-6	PA1216-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006684-7	PA1216-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006684-8	PA1216-FITC	FITC	100 ug	$570		Add to Cart
BHA21006684-9	PA1216-HRP	HRP	100 ug	$570		Add to Cart
BHA21006684-10	PA1216-APC	APC	100 ug	$670		Add to Cart
BHA21006684-11	PA1216-PE	PE	100 ug	$670		Add to Cart
BHA21006684-12	PA1216-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006684-13	PA1216-carrier-free	carrier-free	100 ug	$370		Add to Cart

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