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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Fibroblast growth factor 21 FGF21 Antibody Picoband®

SKU : BHA21006973

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Mfr.No.	PA1673, PA1673-10ug, PA1673-Biotin, PA1673-Cy3, PA1673-Dylight488, PA1673-Dylight550, PA1673-Dylight594, PA1673-FITC, PA1673-HRP, PA1673-APC, PA1673-PE, PA1673-iFluor647, PA1673-carrier-free
Alternative Names	Fibroblast growth factor 21
Background	FGF21 (Fibroblast growth factor 21) is a protein that in humans is encoded by the FGF21 gene, which is also a member of the fibroblast growth factor (FGF) family. The FGF21 gene is mapped on 19q13.33. Using RT-PCR, Fgf21 was expressed in several types of adipose tissue in mice, including subcutaneous and epididymal fat pads and brown adipose tissue. The level of Fgf21 expression in adipose tissue was comparable to that in liver. FGF21 stimulates glucose uptake in adipocytes but not in other cell types. This effect is additive to the activity of insulin. FGF21 treatment of adipocytes is associated with phosphorylation of FRS2, a protein linking FGF receptors to the Ras/MAP kinase pathway. FGF21 also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. Changes in Fgf21 expression due to suckling or nutritional manipulations were associated with changes in circulating free fatty acid and ketone body levels. In differentiated mouse brown adipocytes in culture, Fgf21 treatment increased the expression of thermogenic genes, caused higher total and uncoupled respiration, and enhanced glucose oxidation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Fibroblast growth factor 21 FGF21 Antibody catalog # PA1673. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 [removed]but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human FGF21, different from the related rat and mouse sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	21 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Fibroblast growth factor 21;FGF-21;FGF21;UNQ3115/PRO10196;
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	Q9NSA1
Gene Name	FGF21
Sequence	Belongs to the heparin-binding growth factors family.
Subcellular Location	Secreted .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Galman, C., Lundasen, T., Kharitonenkov, A., Bina, H. A., Eriksson, M., Hafstrom, I., Dahlin, M., Amark, P., Angelin, B., Rudling, M. The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPAR-alpha activation in man. Cell Metab. 8: 169-174, 2008.<br /><br />2. Hondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Igelsias, R., Villarroya, F. Hepatic FGF21 expression is induced at birth via PPAR-alpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 11: 206-212, 2010.<br /><br />3. Nishimura, T., Nakatake, Y., Konishi, M., Itoh, N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim. Biophys. Acta 1492: 203-206, 2000.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006973-1	PA1673	-	100 ug	$370		Add to Cart
BHA21006973-2	PA1673-10ug	Sample	10 ug	$99		Add to Cart
BHA21006973-3	PA1673-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006973-4	PA1673-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006973-5	PA1673-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006973-6	PA1673-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006973-7	PA1673-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006973-8	PA1673-FITC	FITC	100 ug	$570		Add to Cart
BHA21006973-9	PA1673-HRP	HRP	100 ug	$570		Add to Cart
BHA21006973-10	PA1673-APC	APC	100 ug	$670		Add to Cart
BHA21006973-11	PA1673-PE	PE	100 ug	$670		Add to Cart
BHA21006973-12	PA1673-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006973-13	PA1673-carrier-free	carrier-free	100 ug	$370		Add to Cart

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