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Home / Primary Antibodies / Polyclonal Antibodies

Anti-FGFR1 Antibody Picoband®

SKU : BHA21006823

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Mfr.No.	PA1477, PA1477-10ug, PA1477-Biotin, PA1477-Cy3, PA1477-Dylight488, PA1477-Dylight550, PA1477-Dylight594, PA1477-FITC, PA1477-HRP, PA1477-APC, PA1477-PE, PA1477-iFluor647, PA1477-carrier-free
Alternative Names	Fibroblast growth factor receptor 1
Background	FGFR1, Fibroblast growth factor receptor 1, also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2/Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. The FGFR1 gene is localized to 8p12-p11.2 by in situ hybridization. FGFR1 is essential for the normal formation of the organ of Corti and that phenotype severity observed in FGFR1 mutants is dependent on the dose of FGFR1.Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, squamous cell lung cancer and autosomal dominant Kallmann syndrome 2.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-FGFR1 Antibody catalog # PA1477. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patteing and
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human FGFR1, different from the related mouse sequence by two amino acids and rat sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	24 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Fibroblast growth factor receptor 1;FGFR-1;2.7.10.1;Basic fibroblast growth factor receptor 1;BFGFR;bFGF-R-1;Fms-like tyrosine kinase 2;FLT-2;N-sam;Proto-oncogene c-Fgr;CD331;FGFR1;BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR;
Tissue Specificity	Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P11362
Gene Name	FGFR1
Sequence	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. After ligand binding, both receptor and ligand are rapidly intealized. Can translocate to the nucleus after intealization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Pirvola, U., Ylikoski, J., Trokovic, R., Hebert, J. M., McConnell, S. K., Partanen, J. FGFR1 is required for the development of the auditory sensory epithelium.<br /><br />2. Roscioli, T., Flanagan, S., Kumar, P., Masel, J., Gattas, M., Hyland, V. J., Glass, I. A.Clinical findings in a patient with FGFR1 P252R mutation and comparison with the literature.Am. J. Med. Genet. 93: 22-28, 2000.<br /><br />3. Ruta, M., Howk, R., Ricca, G., Drohan, W., Zabelshansky, M., Laureys, G., Barton, D. E., Francke, U., Schlessinger, J., Givol, D.A novel protein tyrosine kinase gene whose expression is modulated during endothelial cell differentiation.Oncogene 3: 9-15, 1988.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006823-1	PA1477	-	100 ug	$370		Add to Cart
BHA21006823-2	PA1477-10ug	Sample	10 ug	$99		Add to Cart
BHA21006823-3	PA1477-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006823-4	PA1477-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006823-5	PA1477-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006823-6	PA1477-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006823-7	PA1477-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006823-8	PA1477-FITC	FITC	100 ug	$570		Add to Cart
BHA21006823-9	PA1477-HRP	HRP	100 ug	$570		Add to Cart
BHA21006823-10	PA1477-APC	APC	100 ug	$670		Add to Cart
BHA21006823-11	PA1477-PE	PE	100 ug	$670		Add to Cart
BHA21006823-12	PA1477-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006823-13	PA1477-carrier-free	carrier-free	100 ug	$370		Add to Cart

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