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Home / Primary Antibodies / Polyclonal Antibodies

Anti-FE65/APBB1 Antibody Picoband®

SKU : BHA21000256

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Mfr.No.	RP1059, RP1059-10ug, RP1059-Biotin, RP1059-Cy3, RP1059-Dylight488, RP1059-Dylight550, RP1059-Dylight594, RP1059-FITC, RP1059-HRP, RP1059-APC, RP1059-PE, RP1059-iFluor647, RP1059-carrier-free
Alternative Names	Amyloid beta A4 precursor protein-binding family B member 1
Background	APBB1 is also known as RIR or FE65. The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alteatively spliced transcript variants encoding different isoforms have been described for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-FE65/APBB1 Antibody catalog # RP1059. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role i
Host	Rabbit
Immunogen Region	E.coli-derived human FE65 recombinant protein (Position: Q295-A613). Human FE65 shares 95%and 96% amino acid (aa) sequence identity with mouse and rat FE65, respectively.
Isotype	Rabbit IgG
Molecular Weight	77 kDa
Reactivity	Human, Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Amyloid beta A4 precursor protein-binding family B member 1;Protein Fe65;APBB1;FE65, RIR;
Tissue Specificity	Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O00213
Gene Id	322
Gene Name	APBB1
Sequence	Contains 2 PID domains.
Subcellular Location	Cell membrane. Cytoplasm. Nucleus. Cell projection, growth cone . Nucleus speckle. Colocalizes with TSHZ3 in axonal growth cone (By similarity). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP. Colocalizes with TSHZ3 in the nucleus. Colocalizes with NEK6 at the nuclear speckles. Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse

Reference	1. Chen GB, et al. Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers. Hum Genet, 2008 Nov. 2. Cheung HN, et al. FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J, 2014 Jan. 3. Ward MW, et al. The amyloid precursor protein intracellular domain(AICD) disrupts actin dynamics and mitochondrial bioenergetics. J Neurochem, 2010 Apr.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000256-1	RP1059	100 ug	-	$370		Add to Cart
BHA21000256-2	RP1059-10ug	10 ug	Sample	$99		Add to Cart
BHA21000256-3	RP1059-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000256-4	RP1059-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000256-5	RP1059-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000256-6	RP1059-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000256-7	RP1059-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000256-8	RP1059-FITC	100 ug	FITC	$570		Add to Cart
BHA21000256-9	RP1059-HRP	100 ug	HRP	$570		Add to Cart
BHA21000256-10	RP1059-APC	100 ug	APC	$670		Add to Cart
BHA21000256-11	RP1059-PE	100 ug	PE	$670		Add to Cart
BHA21000256-12	RP1059-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000256-13	RP1059-carrier-free	100 ug	carrier-free	$370		Add to Cart

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