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Home / Primary Antibodies / Polyclonal Antibodies

Anti-FDPS/FPS Picoband® Antibody

SKU : BHA21002531

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Mfr.No.	A01782-2, A01782-2-10ug, A01782-2-Biotin, A01782-2-Cy3, A01782-2-Dylight488, A01782-2-Dylight550, A01782-2-Dylight594, A01782-2-FITC, A01782-2-HRP, A01782-2-APC, A01782-2-PE, A01782-2-iFluor647, A01782-2-carrier-free
Alternative Names	faesyl diphosphate synthetase
Background	Dimethylallyltranstransferase (DMATT), also known as faesylpyrophosphate synthase (FPPS) or as faesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene. It is mapped to 3 F1; 3 39.01 cM. This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and faesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, faesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein faesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-FDPS/FPS Picoband® Antibody catalog # A01782-2. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key enzyme in isoprenoid biosynthesis which catalyzes the formation of faesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protei
Host	Rabbit
Immunogen Region	E.coli-derived mouse FDPS/FPS recombinant protein (Position: Q12-K347).
Isotype	Rabbit IgG
Molecular Weight	40 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Faesyl pyrophosphate synthase; FPP synthase; FPS; (2E,6E)-faesyl diphosphate synthase; Cholesterol-regulated 39 kDa protein; CR 39; Dimethylallyltranstransferase; Faesyl diphosphate synthase; Geranyltranstransferase; Fdps
Tissue Specificity	Expressed ubiquitously.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Q920E5
Gene Id	110196
Gene Name	Fdps
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Mouse, Rat<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Heinzmann, C., Clarke, C. F., Klisak, I., Mohandas, T., Sparkes, R. S., Edwards, P. A., Lusis, A. J. Dispersed family of human genes with sequence similarity to faesyl pyrophosphate synthetase. Genomics 5: 493-500, 1989. <br /><br />2. Krisans, S. K., Ericsson, J., Edwards, P. A., Keller, G. A. Faesyl-diphosphate synthase is localized in peroxisomes. J. Biol. Chem. 269: 14165-14169, 1994.<br /><br />3. Scott, A. F. Personal Communication. Baltimore, Md. 11/9/2006.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002531-1	A01782-2	-	100 ug	$370		Add to Cart
BHA21002531-2	A01782-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002531-3	A01782-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002531-4	A01782-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002531-5	A01782-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002531-6	A01782-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002531-7	A01782-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002531-8	A01782-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002531-9	A01782-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002531-10	A01782-2-APC	APC	100 ug	$670		Add to Cart
BHA21002531-11	A01782-2-PE	PE	100 ug	$670		Add to Cart
BHA21002531-12	A01782-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002531-13	A01782-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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