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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Fascin/FSCN1 Antibody Picoband®

SKU : BHA21000488

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Mfr.No.	PB9592, PB9592-10ug, PB9592-Biotin, PB9592-Cy3, PB9592-Dylight488, PB9592-Dylight550, PB9592-Dylight594, PB9592-FITC, PB9592-HRP, PB9592-APC, PB9592-PE, PB9592-iFluor647, PB9592-carrier-free
Alternative Names	Fascin
Background	Fascin is an actin cross-linking protein. The Fascin gene contains 5 exons and spans 7 kb. It is a 54-58 kilodalton monomeric actin filament bundling protein originally isolated from sea urchin egg but also found in Drosophila and vertebrates, including humans. Fascin (from the Latin for bundle) is spaced at 11 nanometre intervals along the filament. The bundles in cross section are seen to be hexagonally packed, and the longitudinal spacing is compatible with a model where fascin cross-links at alteating 4 and 5 actins. It is calcium insensitive and monomeric. Fascin binds beta-catenin, and colocalizes with it at the leading edges and borders of epithelial and endothelial cells. The role of Fascin in regulating cytoskeletal structures for the maintenance of cell adhesion, coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective. Abnormal fascin expression or function has been implicated in breast cancer, colon cancer, esophageal squamous cell carcinoma, gallbladder cancer and prostate cancer.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Fascin/FSCN1 Antibody Picoband® catalog # PB9592. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Fascin, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Fascin;55 kDa actin-bundling protein;Singed-like protein;p55;FSCN1;FAN1, HSN, SNL;
Tissue Specificity	Ubiquitous.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	Q16658
Gene Id	6624
Gene Name	FSCN1
Sequence	Belongs to the fascin family.
Subcellular Location	Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. Saishin, Y., Shimada, S., Morimura, H., Sato, K., Ishimoto, I., Tano, Y., Tohyama, M.Isolation of a cDNA encoding a photoreceptor cell-specific actin-bundling protein: retinal fascin.FEBS Lett. 414: 381-386, 1997. 2. Wada, Y., Abe, T., Takeshita, T., Sato, H., Yanashima, K., Tamai, M.Mutation of human retinal fascin gene (FSCN2) causes autosomal dominant retinitis pigmentosa.Invest. Ophthal. Vis. Sci. 42: 2395-2400, 2001.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000488-1	PB9592	100 ug	-	$370		Add to Cart
BHA21000488-2	PB9592-10ug	10 ug	Sample	$99		Add to Cart
BHA21000488-3	PB9592-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000488-4	PB9592-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000488-5	PB9592-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000488-6	PB9592-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000488-7	PB9592-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000488-8	PB9592-FITC	100 ug	FITC	$570		Add to Cart
BHA21000488-9	PB9592-HRP	100 ug	HRP	$570		Add to Cart
BHA21000488-10	PB9592-APC	100 ug	APC	$670		Add to Cart
BHA21000488-11	PB9592-PE	100 ug	PE	$670		Add to Cart
BHA21000488-12	PB9592-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000488-13	PB9592-carrier-free	100 ug	carrier-free	$370		Add to Cart

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