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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Fas Antibody Picoband®

SKU : BHA21006668

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Mfr.No.	PA1119, PA1119-10ug, PA1119-Biotin, PA1119-Cy3, PA1119-Dylight488, PA1119-Dylight550, PA1119-Dylight594, PA1119-FITC, PA1119-HRP, PA1119-APC, PA1119-PE, PA1119-iFluor647, PA1119-carrier-free
Alternative Names	Tumor necrosis factor receptor superfamily member 6
Background	FAS (also known as surface antigen APO1 or CD95) is a member of the tumour-necrosis receptor factor family of death receptors, can induce apoptosis or, conversely, can deliver growth stimulatory signals. It acts as an inducer of both neurite growth in vitro and accelerated recovery after nerve injury in vivo. Fas antigen is expressed and functional on papillary thyroid cancer cells and this may have potential therapeutic significance. The FAS antigen shows structural homology with a number of cell surface receptors, including tumor necrosis factor (TNF) receptors and the low-affinity nerve growth factor receptor (NGFR) and is mapped to 10q24.1. And the FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signalling pathway has been shown to participate in immune escape and tumorigenesis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Fas Antibody catalog # PA1119. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (asparta
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of rat Fas.
Isotype	Rabbit IgG
Molecular Weight	12 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor receptor superfamily member 6;Apo-1 antigen;Apoptosis-mediating surface antigen FAS;FASLG receptor;CD95;Fas;Apt1, Tnfrsf6;
Tissue Specificity	Widely expressed, with highest levels in heart, brain, and skeletal muscle. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q63199
Gene Name	FAS
Sequence	Contains 1 death domain.
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat , By Heat <br>Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Mouse, Rat , -<br>Weste blot, 0.1-0.5ug/ml, Mouse, Rat <br>

Reference	1. Desbarats, J.; Birge, R. B.; Mimouni-Rongy, M.; Weinstein, D. E.; Palerme, J.-S.; Newell, M. K. : Fas engagement induces neurite growth through ERK activation and p35 upregulation. Nature Cell Biol. 5: 118-125, 2003.<br /><br />2. Arscott, P. L.; Stokes, T.; Myc, A.; Giordano, T. J.; Thompson, N. W.; Baker, J. R., Jr. : Fas (CD95) expression is up-regulated on papillary thyroid carcinoma. J. Clin. Endocr. Metab. 84: 4246-4252, 1999.<br /><br />3. Zhang, X.; Miao, X.; Sun, T.; Tan, W.; Qu, S.; Xiong, P.; Zhou, Y.; Lin, D. : Functional polymorphisms in cell death pathway genes FAS and FASL contribute to the risk of lung cancer. J. Med. Genet. 42: 479-484, 2005.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006668-1	PA1119	-	100 ug	$370		Add to Cart
BHA21006668-2	PA1119-10ug	Sample	10 ug	$99		Add to Cart
BHA21006668-3	PA1119-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006668-4	PA1119-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006668-5	PA1119-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006668-6	PA1119-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006668-7	PA1119-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006668-8	PA1119-FITC	FITC	100 ug	$570		Add to Cart
BHA21006668-9	PA1119-HRP	HRP	100 ug	$570		Add to Cart
BHA21006668-10	PA1119-APC	APC	100 ug	$670		Add to Cart
BHA21006668-11	PA1119-PE	PE	100 ug	$670		Add to Cart
BHA21006668-12	PA1119-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006668-13	PA1119-carrier-free	carrier-free	100 ug	$370		Add to Cart

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