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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Fas Antibody Picoband®

SKU : BHA21002472

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Mfr.No.	A00055, A00055-10ug, A00055-Biotin, A00055-Cy3, A00055-Dylight488, A00055-Dylight550, A00055-Dylight594, A00055-FITC, A00055-HRP, A00055-APC, A00055-PE, A00055-iFluor647, A00055-carrier-free
Alternative Names	Fas (TNF receptor superfamily member 6)
Background	FAS (also known as surface antigen APO1 or CD95) is a member of the tumour-necrosis receptor factor family of death receptors. It acts as an inducer of both neurite growth in vitro and accelerated recovery after nerve injury in vivo. FAS antigen is expressed and functional on papillary thyroid cancer cells and this may have potential therapeutic significance. The FAS antigen shows structural homology with a number of cell surface receptors, including tumor necrosis factor (TNF) receptors and the low-affinity nerve growth factor receptor (NGFR) and it is mapped to 10q24.1. The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signalling pathway has been shown to participate in immune escape and tumorigenesis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Fas Antibody Picoband® catalog # A00055. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartat
Host	Rabbit
Immunogen Region	E.coli-derived mouse Fas recombinant protein (Position: E46-K279).
Isotype	Rabbit IgG
Molecular Weight	37 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD_antigen: CD95; Fas; Apt1; Tnfrsf6
Tissue Specificity	Detected in various tissues including thymus, liver, lung, heart, and adult ovary.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P25446
Gene Id	355
Gene Name	Fas
Subcellular Location	Cell membrane. Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, WB
Description	Weste blot, 0.25-0.5ug/ml, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Mouse<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Arscott, P. L., Stokes, T., Myc, A., Giordano, T. J., Thompson, N. W., Baker, J. R., Jr. Fas (CD95) expression is up-regulated on papillary thyroid carcinoma. J. Clin. Endocr. Metab. 84: 4246-4252, 1999.<br /><br />2. Aspinall, A. I., Pinto, A., Auer, I. A., Bridges, P., Luider, J., Dimnik, L., Patel, K. D., Jorgenson, K., Woodman, R. C. Identification of new Fas mutations in a patient with autoimmune lymphoproliferative syndrome (ALPS) and eosinophilia. Blood Cells Molec. Dis. 25: 227-238, 1999.<br /><br />3. Bettinardi, A., Brugnoni, D., Quiros-Roldan, E., Malagoli, A., La Grutta, S., Correra, A., Notarangelo, L. D. Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis. Blood 89: 902-909, 1997.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002472-1	A00055	-	100 ug	$370		Add to Cart
BHA21002472-2	A00055-10ug	Sample	10 ug	$99		Add to Cart
BHA21002472-3	A00055-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002472-4	A00055-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002472-5	A00055-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002472-6	A00055-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002472-7	A00055-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002472-8	A00055-FITC	FITC	100 ug	$570		Add to Cart
BHA21002472-9	A00055-HRP	HRP	100 ug	$570		Add to Cart
BHA21002472-10	A00055-APC	APC	100 ug	$670		Add to Cart
BHA21002472-11	A00055-PE	PE	100 ug	$670		Add to Cart
BHA21002472-12	A00055-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002472-13	A00055-carrier-free	carrier-free	100 ug	$370		Add to Cart

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