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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Factor VII/F7 Antibody Picoband®

SKU : BHA21007272

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Mfr.No.	PA2060, PA2060-10ug, PA2060-Biotin, PA2060-Cy3, PA2060-Dylight488, PA2060-Dylight550, PA2060-Dylight594, PA2060-FITC, PA2060-HRP, PA2060-APC, PA2060-PE, PA2060-iFluor647, PA2060-carrier-free
Alternative Names	Coagulation factor VII
Background	F7 (Coagulation Factor VII), also known as proconvertin, is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class. The F7 gene maps to chromosome 13q34 (Millar et al., 2000). Synthesis of factors VII and X, as well as factors II and IX, takes place in the liver and requires vitamin K. Structural homologies of these factors, which are precursors of serine proteases, have been shown (Zur and Nemerson, 1981). Di Bitondo et al. (2002) used <a href="https://www.bosterbio.com/cells/reporter-cell-lines" style="color:#ea8d28">reporter gene</a> analysis to show that inclusion of promoter regions of F7 reduced transcription activity in the presence of estrogenic factors. The effect was independent of promoter polymorphic haplotype.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Factor VII/F7 Antibody catalog # PA2060. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Factor VII.
Isotype	Rabbit IgG
Molecular Weight	52 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Coagulation factor VII;3.4.21.21;Proconvertin;Serum prothrombin conversion accelerator;SPCA;Eptacog alfa;Factor VII light chain;Factor VII heavy chain;F7;
Tissue Specificity	Plasma.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P08709
Gene Name	F7
Sequence	Belongs to the peptidase S1 family.
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Di Bitondo, R., Hall, A. J., Peake, I. R., Iacoviello, L., Winship, P. R. Oestrogenic repression of human coagulation factor VII expression mediated through an oestrogen response element sequence motif in the promoter region. Hum. Molec. Genet. 11: 723-731, 2002.<br /><br />2. Millar, D. S., Kemball-Cook, G., McVey, J. H., Tuddenham, E. G. D., Mumford, A. D., Attock, G. B., Reverter, J. C., Lanir, N., Parapia, L. A., Reynaud, J., Meili, E., von Felton, A., Martinowitz, U., Prangnell, D. R., Krawczak, M., Cooper, D. N. Molecular analysis of the genotype-phenotype relationship in factor VII deficiency. Hum. Genet. 107: 327-342, 2000.<br /><br />3. Zur, M., Nemerson, Y. Tissue factor pathways of blood coagulation.In: Bloom, A. L.; Thomas, D. P. : Haemostasis and thrombosis. Edinburgh: Churchill Livingstone (pub.) 1981.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007272-1	PA2060	-	100 ug	$370		Add to Cart
BHA21007272-2	PA2060-10ug	Sample	10 ug	$99		Add to Cart
BHA21007272-3	PA2060-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007272-4	PA2060-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007272-5	PA2060-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007272-6	PA2060-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007272-7	PA2060-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007272-8	PA2060-FITC	FITC	100 ug	$570		Add to Cart
BHA21007272-9	PA2060-HRP	HRP	100 ug	$570		Add to Cart
BHA21007272-10	PA2060-APC	APC	100 ug	$670		Add to Cart
BHA21007272-11	PA2060-PE	PE	100 ug	$670		Add to Cart
BHA21007272-12	PA2060-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007272-13	PA2060-carrier-free	carrier-free	100 ug	$370		Add to Cart

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