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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Estrogen Inducible Protein pS2/TFF1 Antibody Picoband®

SKU : BHA21006984

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Mfr.No.	PA1689, PA1689-10ug, PA1689-Biotin, PA1689-Cy3, PA1689-Dylight488, PA1689-Dylight550, PA1689-Dylight594, PA1689-FITC, PA1689-HRP, PA1689-APC, PA1689-PE, PA1689-iFluor647, PA1689-carrier-free
Alternative Names	Trefoil factor 1
Background	TFF1 (Trefoil factor 1), also known as pS2, is a protein that in humans is encoded by the TFF1 gene. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. It is found that TFF1 in normal human urine inhibited the growth of calcium oxalate crystals. Urinary TFF1 showed an inhibitory potency similar to that of nephrocalcin, and inhibition was dose dependent and inhibited by TFF1 antisera, particularly by antisera ed to the TFF1 C terminus. Concentrations and relative amounts of TFF1 in the urine of patients with idiopathic calcium oxalate kidney stones were significantly less than those found in controls. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Estrogen Inducible Protein pS2/TFF1 Antibody catalog # PA1689. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Estrogen Inducible Protein pS2.
Isotype	Rabbit IgG
Molecular Weight	12 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Trefoil factor 1;Breast cancer estrogen-inducible protein;PNR-2;Polypeptide P1.A;hP1.A;Protein pS2;TFF1;BCEI, PS2;
Tissue Specificity	Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P04155
Gene Name	TFF1
Sequence	Contains 1 P-type (trefoil) domain.
Subcellular Location	Secreted .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Chutipongtanate, S., Nakagawa, Y., Sritippayawan, S., Pittayamateekul, J., Parichatikanond, P., Westley, B. R., May, F. E. B., Malasit, P., Thongboonkerd, V.Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor.J. Clin. Invest. 115: 3613-3622, 2005.<br /><br />2. Hanby, A. M., Poulsom, R., Singh, S., Elia, G., Jeffery, R. E., Wright, N. A.Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach.Gastroenterology 105: 1110-1116, 1993.<br /><br />3. Roberts, M., Wallace, J., Jeltsch, J.-M., Berry, M.The 5-prime flanking region of the human pS2 gene mediates its transcriptional activation by estrogen in MCF-7 cells.Biochem. Biophys. Res. Commun. 151: 306-313, 1988. <br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006984-1	PA1689	-	100 ug	$370		Add to Cart
BHA21006984-2	PA1689-10ug	Sample	10 ug	$99		Add to Cart
BHA21006984-3	PA1689-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006984-4	PA1689-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006984-5	PA1689-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006984-6	PA1689-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006984-7	PA1689-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006984-8	PA1689-FITC	FITC	100 ug	$570		Add to Cart
BHA21006984-9	PA1689-HRP	HRP	100 ug	$570		Add to Cart
BHA21006984-10	PA1689-APC	APC	100 ug	$670		Add to Cart
BHA21006984-11	PA1689-PE	PE	100 ug	$670		Add to Cart
BHA21006984-12	PA1689-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006984-13	PA1689-carrier-free	carrier-free	100 ug	$370		Add to Cart

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