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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ErbB 4/ERBB4 Antibody Picoband®

SKU : BHA21007137

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Mfr.No.	PA1881, PA1881-10ug, PA1881-Biotin, PA1881-Cy3, PA1881-Dylight488, PA1881-Dylight550, PA1881-Dylight594, PA1881-FITC, PA1881-HRP, PA1881-APC, PA1881-PE, PA1881-iFluor647, PA1881-carrier-free
Alternative Names	Receptor tyrosine-protein kinase erbB-4
Background	ERBB4 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) also known as ONCOGENE ERBB4 or HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. The ERBB4 gene is mapped on 2q34. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domainbinding motif. Huang et al. (2000) reported that ERBB4 is enriched in the postsynaptic density and associates with PSD95. ERBB4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al. (2001)concluded that gamma-secretase cleavage of ERBB4 may represent another mechanism for receptor tyrosine kinase-mediated signaling.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ErbB 4/ERBB4 Antibody catalog # PA1881. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differen
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 4, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	180 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Receptor tyrosine-protein kinase erbB-4;2.7.10.1;Proto-oncogene-like protein c-ErbB-4;Tyrosine kinase-type cell surface receptor HER4;p180erbB4;ERBB4 intracellular domain;4ICD;E4ICD;s80HER4;ERBB4;HER4;
Tissue Specificity	Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q15303
Gene Name	ERBB4
Sequence	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Subcellular Location	Cell membrane ; Single-pass type I membrane protein . In response to NRG1 treatment, the activated receptor is intealized.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Huang, Y. Z., Won, S., Ali, D. W., Wang, Q., Tanowitz, M., Du, Q. S., Pelkey, K. A., Yang, D. J., Xiong, W. C., Salter, M. W., Mei, L. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26: 443-455, 2000.<br /><br />2. Ni, C.-Y., Murphy, M. P., Golde, T. E., Carpenter, G.Gamma-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294: 2179-2181, 2001.<br /><br />3. Sardi, S. P., Murtie, J., Koirala, S., Patten, B. A., Corfas, G. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 127: 185-197, 2006.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007137-1	PA1881	-	100 ug	$370		Add to Cart
BHA21007137-2	PA1881-10ug	Sample	10 ug	$99		Add to Cart
BHA21007137-3	PA1881-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007137-4	PA1881-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007137-5	PA1881-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007137-6	PA1881-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007137-7	PA1881-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007137-8	PA1881-FITC	FITC	100 ug	$570		Add to Cart
BHA21007137-9	PA1881-HRP	HRP	100 ug	$570		Add to Cart
BHA21007137-10	PA1881-APC	APC	100 ug	$670		Add to Cart
BHA21007137-11	PA1881-PE	PE	100 ug	$670		Add to Cart
BHA21007137-12	PA1881-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007137-13	PA1881-carrier-free	carrier-free	100 ug	$370		Add to Cart

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