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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Eotaxin/Ccl11 Antibody

SKU : BHA21003922

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Mfr.No.	A01438-2, A01438-2-10ug, A01438-2-Biotin, A01438-2-Cy3, A01438-2-Dylight488, A01438-2-Dylight550, A01438-2-Dylight594, A01438-2-FITC, A01438-2-HRP, A01438-2-APC, A01438-2-PE, A01438-2-iFluor647, A01438-2-carrier-free
Alternative Names	bestrophin 1
Background	CCL11 (Chemokine (C-C motif) ligand 11), also known as Eotaxin, is a small cytokine belonging to the CC chemokine family. Eotaxin selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of Eotaxin are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which Eotaxin is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. The gene for human Eotaxin is encoded on three exons and is located on chromosome 17q12.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Eotaxin/Ccl11 Antibody Picoband® catalog # A01438-2. Tested in ELISA, IHC applications. This antibody reacts with Rat.
Function	Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.
Host	Rabbit
Immunogen Region	E.coli-derived rat Eotaxin/Ccl11 recombinant protein (Position: H24-P97).
Isotype	Rabbit IgG
Molecular Weight	75 kDa
Reactivity	Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2; BEST1; VMD2
Tissue Specificity	Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P97545
Gene Id	29397
Gene Name	Ccl11
Subcellular Location	Cell membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	IHC, ELISA
Description	Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Rat ELISA, 0.1-0.5 ug/ml, Rat

Reference	1. Menzies-Gow, A., Ying, S., Sabroe, I., Stubbs, V. L., Soler, D., Williams, T. J., Kay, A. B.Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers.J. Immun. 169: 2712-2718, 2002. 2. Shin, H. D., Kim, L. H., Park, B. L., Jung, J. H., Kim, J. Y., Chung, I.-Y., Kim, J. S., Lee, J. H., Chung, S. H., Kim, Y. H., Park, H.-S., Choi, J. H., Lee, Y. M., Park, S. W., Choi, B. W., Hong, S.-J., Park, C.-S.Association of eotaxin gene family with asthma and serum total IgE.Hum. Molec. Genet. 12: 1279-1285, 2003. Note: Erratum: Hum. Molec. Genet. 12: 2083 only, 2003. 3. Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., Lucin, K. M., Czirr, E., and 11 others.The ageing systemic milieu negatively regulates neurogenesis and cognitive function.Nature 477: 90-94, 2011.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003922-1	A01438-2	-	100 ug	$370		Add to Cart
BHA21003922-2	A01438-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003922-3	A01438-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003922-4	A01438-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003922-5	A01438-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003922-6	A01438-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003922-7	A01438-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003922-8	A01438-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003922-9	A01438-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003922-10	A01438-2-APC	APC	100 ug	$670		Add to Cart
BHA21003922-11	A01438-2-PE	PE	100 ug	$670		Add to Cart
BHA21003922-12	A01438-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003922-13	A01438-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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